眼底病             3281                                      AB1054

    Visual Acuity Change after Intravitreal Triamcinolone in Various Types of Exudative Age-Related Macular Degeneration

    Jost B. Jonas, MD, Vanessa Strueven, Bernd A. Kamppeter, MD, Bjoern Harder,MD, Ulrich H. Spandau, MD, and Frank Schlichtenbrede, MD

    Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the University Heidelberg, Germany

   Objective. To compare the visual acuity change after an intravitreal high-dose injection of triamcinolone acetonide in various types of exudative age-related macular degeneration.

    Participants. The interventional comparative case series study included 142 patients (146 eyes) with progressive exudative age-related macular degeneration differentiated into the occult type (n=78; 53.4%), minimal classic type (n=45; 30.8%), predominantly classic type (n=17; 11.6%), and the purely classic type (n=6; 4.1%). Mean follow-up was 9.7  7.0 months (3 – 35.7 months).

    Methods. Single intravitreal injection of about 20 mg triamcinolone acetonide.
Outcome measures. Visual acuity, intraocular pressure.

    Results. Gain in visual acuity measured at one month (P=0.20), two months (P=0.43), and at three months (P=0.38) after the intravitreal injection of triamcinolone and maximal gain in visual acuity during the whole follow-up (P=0.81) did not vary significantly between the four study groups. Correspondingly, the size of a retinal pigment epithelium detachment was not significantly associated with the change in visual acuity at 1 month (P=0.62), 2 months (P=0.24), 3 months (P=0.96) or the maximal gain in visual acuity during follow-up (P=0.93). The amount of rise in intraocular pressure compared with the baseline value (6.5  7.4 mm Hg) was statistically not associated with the type of subfoveal membrane (P=0.20; 95%CI: -0.52, 2.45).

    Conclusions. The change in visual acuity and the rise in intraocular pressure in patients with exudative age-related macular degeneration receiving an intravitreal triamcinolone monotherapy is statistically independent of the type of subfoveal membrane including the size of a retinal epithelium detachment.

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