Retinal Pigment Epithelium Tear after Intravitreal Bevacizumab for Exudative Age-Related Macular Degeneration

Jost B. Jonas MD, Ulrich H.M. Spandau MD
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the Ruprecht-Karls-University Heidelberg, Germany

Purpose. To report on the development of retinal pigment epithelium tears after intravitreal injections of bevacizumab as treatment of exudative age-related macular degeneration.
Design. Interventional case series.
Methods. The study included 63 patients who received an intravitreal injection of 1.5 mg bevacizumab as treatment of a detachment of the retinal pigment epithelium due to age-related macular degeneration and who had a follow-up of at least 2 months.
Results. Four (6%) patients developed a tear of the retinal pigment epithelium in the parafoveal region. Compared with the baseline value, visual acuity at the end of follow-up remained stable in three patients and declined in the fourth patient.
Conclusions. Intravitreal injections of bevacizumab may be followed by a tear of the retinal pigment epithelium in eyes with exudative age-related macular degeneration and a retinal pigment epithelium detachment

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