¡¡¡¡Ocular anomalies occurred in 13 patients (40.6%) in our group, but only 3 patients showed anterior lenticonus, and 2 patients showed perimacular retinal flecks. It had been reported that ocular characteristic changes always occurred in the late stage of Alport syndrome. Relatively long course of disease (13.2 years vs 9.3 years) and lower positive rate of patients with characteristic changes in our group also confirmed this viewpoint. In this study, we also found that the characteristic ocular changes occurred in patients with Alport syndrome, especially the anterior lenticonus, was mostly accompanied by sensorineural deafness and renal failure. The findings may suggest that occurrence of ocular characteristic changes, especially the anterior lenticonus, implies a worse prognosis of patients with Alport syndrome.

¡¡¡¡In summary, ocular anomalies are not requisite for the diagnosis of Alport syndrome. But ocular examination is a precious help for the diagnosis. Ocular anomalies, especially the typical ones can also determine the prognosis of nephropathy. When confronted with such patients, we should get their renal investigations and audiology examination for an early diagnosis of Alport syndrome and appropriate treatment.

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