文献报道，以PCNA作为细胞增殖检测指标显示，bFGF有显著促人晶状体上皮细胞增殖作用[9]。但在本实验中，随着bFGF浓度增加，PCNA表达的阳性率增加，但是各组间差异不具有统计学意义，推测是由于培养液中胎牛血清浓度控制在较低水平，从而抑制了晶状体上皮细胞的增殖作用。本实验提示，低浓度bFGF (5μg/L)对体外培养的划痕损伤区细胞迁移起促进作用，此种作用与FAK mRNA表达上调有关，但是随浓度升高，此种作用消失。高浓度bFGF (15μg/L)反而对细胞迁移起明显的抑制作用，此时FAK mRNA表达也抑制。由此可见，FAK在bFGF引起的人晶状体上皮细胞迁移的双相调节中起重要作用。

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