【关键词】 ,Graves眼病;儿童;特征
【摘要】 目的 观察儿童Graves眼病的临床特征及治疗的频率。方法 回顾1994~2004年18岁和18岁以下诊断为Graves眼病患儿的一组资料。结果 32例Graves眼病儿童,其中女25例(78.1%),男7例(21.9%)。初诊时,5例患儿(15.6%)有甲状腺功能亢进,1例患儿(3.1%)有甲状腺功能减退,26例患儿(81.3%)甲状腺功能正常。诊断为甲状腺功能障碍的平均年龄为13岁(3~18岁)。诊断为Graves眼病的平均年龄为15岁(5~18岁)。28例患儿(87.5%)仅用支持疗法,1例患儿(3.1%)行眼睑手术,3例患儿(9.4%)行眶脂减压术。追踪观察5年(1~10年),有1例患儿(3.1%)实施了眼肌手术。结论 儿童Graves眼病临床表现相对来说不很严重,很少需要手术治疗。
【关键词】 Graves眼病;儿童;特征
Clinical observation of Graves ophthalmopathy in pediatric patients
XU Feng-lan,YU Chang-tai,LIU Ai-shu,et al.Department of Ophthalmology,The General Hospital of Qianjiang City,Hubei 433100,China
【Abstract】 Objective To observe the clinical characteristics and the frequencies of treatment of children with Graves ophthalmopathy.Methods Retrospectively, patients 18 years or younger in Graves ophthalmopathy was diagnosed from 1994 to 2004.Results The 32 children with Graves ophthalmopathy included 25 girls (78.1%) and 7 boys (21.9%).At the time of initial ophthalmic exqmination,5 patients (15.6%) were hyperthyroid,1 patient (3.1%)was hypothyroid,and 26 patients (81.3%) were euthyroid.The mean age at diagnosis of thyroid dysfunction was 13 years (range,3 to 18).The mean age at diagnosis of ophthalmopathy was 15 years (range,5 to 18).Twenty-eight patients (87.5%) required no therapy or only supportive theeyapy.One patient (3.1%) required eyelid surgery.Three patients (9.4%) underwent orbital decompression.At a mean follow-up 5 years (range,1~10) after the initial examination,one patient (3.1%) had undergone eye muscle surgery.Conclusion The clinical manifestations of Graves ophthalmopathy are relative less severe in pediatric patients.Surgical therapy is infrequently necessary.
【Key words】 Graves ophthalmopathy; pediatric patients; clinical features
儿童Graves眼病资料在国内文献中很少见到,本文将我院10年间收集到的一组病例资料报告如下。
1 资料与方法
1.1 一般资料 采用回顾性研究,收集我院1994~2004年间18岁和18岁以下诊断为Graves眼病的一组病例资料共32例,其中男7例(21.9%),女25例(78.1%)。初诊时5例患儿(15.6%)FT3、FT4、TSH检查超过正常,1例患儿(3.1%)结果低于正常,26例患儿(81.3%)结果正常。3例患儿(9.4%)其家庭成员中有Graves眼病,10例患儿(31.3%)其家族成员中有甲状腺功能障碍。
1.2 观察方法 每个患儿初诊时均做裂隙灯检查,检查上下睑位置和运动情况,检查眼球运动和做复像分析,测定眼压,测定眼球突出度,并拍眼眶CT片。追踪观察期内,每月随访检查1次。
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