IGF在实验性近视眼后极部巩膜重塑过程中起调控作用[10]。Seko等[5]已经从实验性近视发现许多生长因子，包括bFGF、TGF-β、IGF-1、IGF-2等都能促进巩膜的生长、增殖，在体外培养的巩膜软骨细胞和纤维细胞中加入IGF-1和IGF-2后均可促进巩膜软骨细胞的增殖，抑制纤维母细胞的增殖和胞外基质的合成。另有研究也发现，IGF-1刺激巩膜细胞增殖的过程与刺激胚胎期巩膜生长的机制相类似[11-13]。Tokoro等[11]也发现IGF-1与近视的发展有关。本研究结果显示：近视组血清IGF-1浓度明显高于对照组，差异有显著性（P<0.01）。三种近视程度组（低、中、高）的血清IGF-1浓度经两两比较，差异均有显著性（P<0.05），血清IGF-1浓度与近视程度呈正相关（P<0.01）,也与眼轴长度、屈光度存在正相关性（P<0.05），而与身高、体重、角膜屈光力无明显关系（P>0.05）。这些结果都说明了IGF-1与近视的形成、发生、发展有关。

    然而，本研究尚不能回答血清IGF-1浓度与近视的因果关系，况且IGF-1与近视的关系研究只是开始，因此，IGF-1与近视的关系有待于进一步的分析和研究。

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