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Bevacizumab(avastin)在眼科中的应用前景

http://www.cnophol.com 2008-7-10 13:11:08 中华眼科在线

参考文献:
[1]MOSHFEGHI AA,ROSENFELD PJ,PULIAFITO CA,et al.Systemic bevacizumab(avastin)therapy for neovascular age-related macular degeneration:24-week results of an uncontrolled,open label clinical study[J].Ophthalmology,2006,113(11):1-12.
[2]SLEDGE G,MILLER K,NOVOTNY W,et al.A phase Ⅱ trial of singleangent rhuMAb VEGF(recombinant humanized monoclonal antibody to vascular endothelial cell gowth)in patients with relapsed metastatic breast cancer[J].36th Annual Meeting of the American Society of Clinical Oncology.2000,20(19):3-20
[3]ROSENFELD PJ,MOSHFEGHI AA,PULIAFITO CA.Optical coherence tomography findings after an intravitreal injection of bevacizumab(avastin)for neovascular age-related macular degeneration[J].Ophthal Surg Laser Imag,2005,36(4):331-335.
[4]GEITZENAUER W,MICHELS S,PRAGER F,et al.Early effects of systemic and intravitreal bevacizumab(avastin(R)):therapy for neovascular age-related macular degeneration[J].Klin Monatsbl Augenheilkd,2006,223(10):822-827.
[5]FUNG AE,ROSENFELD PJ,REICHEL E.The international intravitreal bevacizumab safety survey:using the internet to assess drug safety worldwide[J].Br J Ophthalmol,2006,90(11):1344-1349.
[6]NICOLO M,GHIGLIONE D,CALABRIA G.Retinal pigment epithelial tear following intravitreal injection of bevaeizumab(avastin)[J].Eur J Ophthalmol.2006,16(5):770-773.
[7]COSTA RA,JORGE R,CALUCCI D,et al.Intravitreal bevacizumab for choroidal neovascularization caused by AMD(IBeNA study):results of a phase 1 dose-escalation study[J].Invest Ophthalmol Vis Sci,2006,47(10):4569-4578.
[8]LAZIC R,GABRIC N.Intravitreally administered bevacizumab(avastin)in minimally classic and occult choroidal neovascularization secondary to agerelated macular degeneration[J].Graefes Arch Clin Exp Ophthalmol,2007,245(1):68-73.
[9]NGUYEN QD,SHAH S,TATLIPINAR S,et al.Bevacizumab suppresses choroidal neovascularisation caused by pathological myopia[J].Br J ophthalmol,2005,89(10):1368-1370.
[10]LAUD K,SPAIDE RF,FREUND KB,et al.Treatment of choroidal neovascularization in pathologic myopia with intravitreal bevacizumab[J].Retina,2006,26(8):960-963.
[11]SOLIMAN W,LAUD AH,LARSEN M.Resolution of subretinal haemorrhage and fluid after intravitreal bevacizumab in aggressive peripapillary subretinal neovascularization[J].Acta Ophthalmol Scand,2006,84(5):707-708.
[12]TEIXEIRA A,MORAES N,FARAH ME,et al.Choroidal neovascularization treated with intravitreal injection of bevacizumab(avastin)in angioid streaks[J].Acta Ophthalmol Scand,2006,84(6):835-836.
[13]SPAIDE RF,FISHER YL.Intravitreal bevacizumab(avastin)treatment of proliferative diabetic retinopathy complicated by vitreous hemorrhage[J].Retina,2006,26(3):275-278.
[14]AVERY RL,PEARLMAN J,PIERAMICI DJ,et al.Intravitreal bevacizumab(avastin)in the treatment of proliferative diabetic retinopathy[J].Ophthalmol,2006,113(10):1695-1715.
[15]DAVIDORF FH,MOUSER JG,DERICK RJ.Rapid improvement of rubeosis iridis from a single bevacizumab(avastin)injection[J].Retina,2006,26(3):354-356.
[16]SIQUEIKA RC,COSTA RA,SCOTY IU,et al.Intravitreal bevacizumab(avastin)injection associated with regression of retinal neovascularization caused by sickle cell retinopathy[J].Acta Ophthalmol Scand,2006,84(6):834-835.
[17]SHAH PK,NARENDRAN V,TAWANSY KA,et al.Intravitreal bevacizumab(avastin)for post laser anterior segment ischemia in aggressive posterior retinopathy of prematurity[J].Indian J Ophthalmol,2007,55(1):75-76.
[18]BOM AGGIO F,EID FARAH M,MELO GB.Intravitreal bevacizumab for occult choroidal neovascularization with pigment epithelium detachment in age-related macular degeneration[J].Acta Ophthalmol Scand,2006,84(5):713-714.
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继续教育试题
选择题:
1.Bevacizumab与VEGF的结合点有:( )
  A.1个         B.2个          C.3个          D.4个
2.发达国家60岁以上人群首位致盲原因是:( )
  A.PDR         B.AMD           C.CRVO         D.VH
3.AMD患者中,致盲原因90%是因为:( )
  A.CNV         B.CRVO          C.CFT          D.VH
4.Bevacizumab是VEGF的单克隆抗体,其大小是:( )
  A.145kb       B.149kb         C.157kb        D.160kb
5.Bevacizumab最早用于临床是治疗:( )
  A.AMD         B.PDR           C.VH           D.PED
填空题:
1.玻璃体腔内注射bevacizumab治疗CNV对轻微典型型、         和          短期应用均有效,没有明显的安全性问题。
2.Bevacizumab玻璃体腔内注射有引起一过性幻视或RPE撕裂的报道,因此对伴较大     的AMD患者应慎用。
3.光凝可减少CNV导致的严重视力下降的风险,但对中心凹下、         和         等多种情况无法应用。
简答题:
1.简述Bevacizumab全身用药及玻璃体腔内注射的不良反应。
2.简述Bevacizumab可用于临床那些眼科疾患?

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