眼底病 3348 AB1057
Erythropoietin Levels in Aqueous Humour in Eyes with Exudative Age-Related Macular Degeneration and Diabetic Retinopathy
Jost B. Jonas, MD (1), and Michael Neumaier, MD (2)
(1) Department of Ophthalmology, and (2) Institute for Clinical Chemistry, Faculty of Clinical Medicine Mannheim of the University Heidelberg, Germany
Purpose. To evaluate whether the concentration of erythropoietin as another potent ischemia-induced angiogenic factor is elevated in eyes with neovascular maculopathies.
Design. Clinical comparative interventional study.
Participants and Methods. The study included 28 patients with diabetic macular edema, 59 patients with exudative age-related macular degeneration (AMD), and 49 patients with cataract. For all patients, aqueous humour was collected during cataract surgery or during an intravitreal injection of triamcinolone acetonide. Erythropoietin levels were measured using a solid-phase chemiluminescence immunoassay.
Results. The mean concentration of erythropoietin was significantly higher in the diabetic group (60.1  46.7 mUnits/mL; p<0.001) than in the age-related macular degeneration group (22.9  23.2 miili units / mL) and in the control group (22.0  21.0 mUnits / mL; p<0.001). The two latter groups did not vary significantly (p=0.41).
Conclusions. Erythropoietin may be present in considerably higher concentrations in eyes with diabetic macular edema than in eyes with exudative AMD or normal eyes.
声明：本站独家报道转载请标明“中华眼科在线” |
