Yu-Mei Chung (张由美)
Uveitis Service, Department of Ophthalmology, National Yang-Ming University School of Medicine and Taipei Veterans General Hospital, Taipei, Taiwan

The RPE is located at the critical interface between the systemic circulation and the neural retina. The roles of RPE are diverse; it may a participant in the reparative process, may be a regulator of the local immune response, or may play a pivotal role in some disease process. In response to certain alterations in the microenviroment, RPE may be activated and proliferation and/or migration results.
Although the exact etiology of VKH is unknown, it is thought to be a primary inflammatory condition directed against melanin-containing cells including RPE.
The etiology of serpiginous chroiditis is not known, but it is believed to be a chronic recurring inflammation that primary affects the inner choroid and RPE. In Behcet’s disease, repeated inflammatory bouts with the most vision-robbing pathology located in the posterior pole, with occluded “silver-wired” vessels and a variable degree of chorioretinal scars, RPE alternation, and optic nerve atrophy. The clinical presentation of primary intraocular lymphoma (PIOL) is diversed. In the initial stage of PIOL, the most common finding is a disturbance at the RPE level, showing granularity, mottling and late staining. A healed Toxoplasma scar typically has well-defined borders with central retinochoroidal atrophy and peripheral pigment epithelial hyperplasia. 
   Association of RPE and several intraocular inflammatory diseases will be demonstrated.  
RPE在葡萄膜炎中扮演的角色是多样的. 一般来说是扮演修复者, 有时又是一个积极参与者, 甚至是主导者. 就几个与RPE有关的葡萄膜炎疾病提出说明.

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