郑曰忠
天津市眼科医院 300020
Noninfectious uveitis is a significant sight-threatening problem in the working age population.Corticosteroids are typically used as the initial drug therapy.Steroids-resistant uveitis is a group of uveitis that was irresponsible or relapses frequently to routine corticosteroids treatment.The common types were Behcet uveitis，serpiginous choroidopathy，multifocal choroiditis with panuveitis，birdshot retinochoroidopathy，uveitis with juvenile idiopathic arthritis，sarcordosis，intermediate uveitis，relapsed Vogt-Koyanagi-Harada disease and sympathetic ophthalmia.Most of this kind of uveitis was need the combined therapy of corticosteroids and immunosuppressive agents or biologic agents.The common immunomodulatory drugs include T-cell inhibitors，antimetabolites and alkylating agents，the common biological agents include Targeting Lymphocyte subsets，tumor necrosis factor antagonists，interferons-α，interleukin receptors antagonists and other biologic agents.Given that immunomodulatory drugs have their individual differing indications and side effects，treatment should be individualized and closely monitored. |
