【摘要】  目的 研究黄斑色素密度与对比敏感度功能之间的关系，探讨黄斑色素对视功能的影响。方法 采用异色闪烁光度仪对116例正常香港青年的右眼进行黄斑色素密度测量。挑选黄斑色素密度值超过0.90 和低于0.40的受试者，将他们分为高黄斑色素密度组和低黄斑色素密度组。采用VSG系统软件对两组右眼进行空间、时间对比敏感度功能测量。结果 116例受试者右眼黄斑色素密度值为0.64±0.30。高密度组在各个空间频率与时间频率下的对比敏感度值都高于低密度组；高、低黄斑色素密度组的条栅视力分别为（33.01±3.35）c/d和（30.83±2.88）c/d；闪光融合频率分别是（37.69± 6.82）Hz和（36.24±5.00）Hz。但两组空间、时间对比敏感度功能差异无显著性。结论 为了进一步证实黄斑色素与视功能之间的关系，需要在这一方面进行更多的研究。

【关键词】  黄斑色素；叶黄素；玉米黄质；对比敏感度

    ［Abstract］  Objective  To investigate the relationship between the level of macular pigment optical density and contrast sensitivity in visual function. Methods  The macular pigment optical density (MPOD) was measured in the right eye of 116 adult subjects. Subjects with an MPOD over 0.90 (high MPOD) and less than 0.40 (low MPOD) were invited to participate in spatial and temporal contrast sensitivity measurements. Results  The mean MPOD (±SD) was 0.64±0.30 for 116 subjects. The contrast sensitivity under each spatial and temporal frequency was higher for the high MPOD group than that for low MPOD group. Grating acuities were （33.01± 3.35）c/d and （30.83±2.88）c/d for each of the two groups, respectively. Critical flicker frequencies (CFF) were (37.69±6.82)Hz and (36.24±5.00)Hz for the high and low MPOD groups, respectively. But no statistically significant difference was found between the two groups for spatial and temporal contrast sensitivity functions. Conclusion  The differences between the high MPOD group and low MPOD group are interesting and further research on the relationship between MPOD and visual function should be conducted.

    [Key words]   macular pigment； lutein； zeaxanthin； contrast  sensitivity

     黄斑是位于灵长类动物视网膜后极部的一个色素性区域, 黄斑中心凹是视网膜上产生敏锐视觉的部位。近年来针对黄斑区色素（macular pigment, MP）的研究已成为一大热点。黄斑色素对视网膜的保护机制假说均提示，黄斑色素可以提高视功能。基于这一点，本研究通过测量正常青年人的黄斑色素密度、空间及时间对比敏感度，研究黄斑色素密度与对比敏感度功能之间的关系，探讨黄斑色素对视功能的影响机制。

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