【摘要】  目的：探讨药物性角膜病变的临床特征，以提醒临床医生注意，预防此类疾病的发生。方法：对临床所见24例34眼药物性角膜病变的临床资料进行回顾性总结分析。 结果：角膜病变轻者，短期用药即可恢复角膜上皮混浊水肿消退，角膜透明视力增加。角膜病变重用药时间长者，大约2～4wk才可完全恢复。结论：药源性角膜病变多由眼局部不合理用药引起，其临床表现多为非特异性，不同滴眼剂所致角膜毒性的发病机制不尽相同，临床眼科医生应关注滴眼剂对角膜的毒性作用，并积极预防和治疗，规范用药、预防发生是关键。

【关键词】  滴眼剂;药物毒性；角膜病变

      Clinical analysis of drug toxic keratopathy

    Xiao-Hui Yang

    Department of Ophthalmology, People's Hospital of Ji County, Tianjin 301900, China

    Abstract AIM: To study the clinical features of drug toxic keratopathy so as to raise the attention of doctors on its prevention.METHODS: The clinical data of 24 cases (34 eyes) with drug toxic keratopathy were retrospectively analyzed.  RESULTS: The drug toxic keratopathy is mainly caused by improper local drug usage with non-specifity as its major clinical manifestation. CONCLUSION: Since the mechanisms of keratopathy caused by different drugs vary each other, doctors should pay attention to the toxicity of eye drops on the cornea, and standardized durg usage and proper prevention are the keys to active treatment of the drug toxic keratopathy.

    · KEYWORDS: eye drop; drug toxicity; keratopathy

   0引言

    随着医药技术的不断发展,目前临床上可供选择的滴眼剂越来越多,抗菌药物、抗病毒药及非甾体类消炎药等的广泛应用虽然为临床治疗提供了多种选择机会,但是某些滴眼剂的眼表毒性反应也越来越多见。尤其是滥用药物,不仅增加患者的经济负担,而且可能发生药物引发的角膜病变。现将2002-06/2006-10观察到的药物引发的角膜病变24例34眼临床资料分析报告如下。

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