[摘要] 目的 研究雪旺细胞标记物神经细丝酸性蛋白(GFAP)在腺样囊性癌有嗜神经性侵袭组与无嗜神经性侵袭组中的表达的差异,旨在进一步探明泪腺腺样囊性癌嗜神经性侵袭性生长的机制。方法 应用免疫组化S-P法检测GFAP在28例腺样囊性癌中的表达情况。结果 有嗜神经侵袭性生长组中的GFAP阳性表达率较无嗜神经侵袭性生长组呈升高趋势(P<0.05)。结论 泪腺腺样囊性癌的嗜神经性侵袭特性可能与肿瘤细胞中存在着雪旺细胞分化有关。
[关键词] 泪腺腺样囊性癌;神经细丝酸性蛋白;嗜神经性侵袭性;雪旺细胞分化
Expression and significance of GFAP in lacrimal adenoid cystic carcinoma
WANG Leifeng,ZHU Sufang,HEI Yan,et al.The Second Hospital of Beijing CAPF,Beijing 100037,China
[Abstract] Objective To investigate the expression of Schwanns cell markers GFAP in lacrimal gland adenoid cystic carcinoma.
Methods S-P(Streptavidin/Peroxidase) immunohistochemical staining was used to determine the expression of GFAP in 28 lacrimal gland adenoid cystic carcinoma.
Results GFAP in norneural invasion group and neural invasion group was 0 and (2.07±3.01),respectively,in lacrimal gland adenoid cystic carcinoma (P<0.05).
Conclusion The Schwanns cell differentiation may account histologically for the neural invasion of lacrimal gland adenoid cystic carcinoma.
[Key words] lacrimal adenoid cystic carcinoma; GFAP; neural invasion; Schwanns cell differentiation
在恶性泪腺上皮性肿瘤中,腺样囊性癌最为常见并且恶性程度最高,由于复杂的局部解剖,加之腺样囊性癌具有浸润性生长和嗜神经性侵袭的特点,手术无法保证切除所有肿瘤,治疗比较棘手[1]。腺样囊性癌嗜神经侵袭生长的特性,常导致患者出现疼痛、麻木等周围神经受损症状或体征。并且由于肿瘤细胞易沿神经生长,使得手术切除范围非常不易掌握。泪腺腺样囊性癌的嗜神经性侵袭性生长的特性是目前腺样囊性癌研究的热点问题之一。有学者推测腺样囊性癌细胞发生雪旺细胞分化可能是腺样囊性癌嗜神经侵袭的机制之一[2]。常见的雪旺细胞标志物有S-100蛋白、神经细丝酸性蛋白(GFAP)等。本研究检测了GFAP在腺样囊性癌有嗜神经性侵袭组与无嗜神经性侵袭组中的表达。目的在于探讨泪腺腺样囊性癌嗜神经性侵袭性生长的机制。最终有利于临床医生对腺样囊性癌的嗜神经侵袭特性采取更有效的针对性手段,控制腺样囊性癌的侵袭和复发。
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