6.3眼科治疗 联合全身药物和眼科早期干预可以减轻眼部病损程度。单纯全身应用药物对于眼部并发症的改善无效。即使全身症状控制,眼部病损改善不满意。眼部治疗目的是缓解眼部的症状及并发症,针对不同类型的病变,采用局部药物治疗或手术干预。如坏死性角巩膜炎局部可使用糖皮质激素,合并感染使用抗生素,干眼使用人工泪液等。如泪道阻塞可采用鼻腔泪囊吻合术,角膜穿孔采用结膜瓣覆盖,角膜移植术,合并视力丧失为解决眼球外观可采用眼内容剜除并义眼台植入。眼眶畸形可进行整形等。
WG是一种机制不明的致死性的全身疾病,早期诊断和治疗至关重要,近年出现了一些新的检验技术和治疗方法,大大提高了对本病的诊疗水平。对于以眼科首诊和仅有眼部表现的可疑病例,眼科医生要注意鉴别,及时行ANCA检查,反复取活检,请多科参与诊治。全身药物治疗的同时,眼部也要给予药物或/和手术干预,以减轻眼部病损。
【参考文献】 1 Takwoingi YM, Dempster JH. Wegener’s granulomanatosis of 33 patients over a 10-year period. Clin Otolaryngol ,2003;28:187-194
2 Cotch MF, Hoffman GS, Yerg DE. The epidemiology of Wegener's granulomatosis. Estimates of the five-year period prevalence, annual mortality, and geographic disease distribution from population-based data sources.Arthritis Rheum ,1996;39(1):87-92
3 Gencik M, Borgmann S, Zahn R, Albert E, Sitter T, Epplen JT, Fricke H. Immunogenetic risk factors for anti-neutrophil cytoplasmic antibody(ANCA)-associated systemic vasculitis. Clin Exp Immunol ,1999;117:412-417
4 Popa ER, Stegeman CA, Kallenberg CG, Tervaert JW. Staphylococcus aureus and Wegener's granulomatosis. Arthritis Res ,2002;4(1):77-79
5 Hewins P, Tervaert JW, Savage CO, Kallenberg CG. Is Wegener’s granulomatosis an autoimmune disease? Curr Opin Rheumatol ,2000;12(1):3-10
6 Watorek E,Boratynska M, Klinger M. Wegener’s granulomatosis-autoimmunity to nertrophil proteinase 3. Arch Immunol Ther Exp(Warsz) ,2003;51:157-167
7 Cluter WM, Blatt IM. The ocular manifestations of lethal midline granuloma ( Wegener's granulomatosis).Am J Ophthalmol ,1956;42:21-35
8 Fauci AS, Haynes BF, Katz P, Wolff SM. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients 21 years. Ann Intern Med ,1983;98:76
9 Kenneth E. Sack. Wegener'Granulomatosis(Medical Staff Conference).Wesrt J Med ,1989;150:329-333
10 Harper SL, Letko E, Samson CM, Zafirakis P, Sangwan V, Nguyen Q, Uy H, Baltatzis S, Foster CS. Wegener's granulomatosis: the relationship between ocular and systemic disease. J Rheumatol ,2001;28(5):1025-1032
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