【摘要】 目的：探讨糖尿病视网膜病变（diabetic retinopathy, DR）眼底镜及眼底荧光血管造影（fundus fluorescence angiography, FFA）检查表现的差异，评价FFA在DR早期诊断中的价值。方法：经我院内分泌科确诊为糖尿病的患者分别行散瞳眼底镜检查及FFA检查，行DR临床分期，分析总结两者的表现差异。结果：120例（238眼）糖尿病患者中，眼底镜下“正常眼底”42眼中FFA修正诊断为非增殖性糖尿病视网膜病变（nonproliferative diabetic retinopathy, NDR）Ⅰ期者11眼，修正诊断为NDRⅢ期者3眼；眼底镜下NDR176眼中FFA修正诊断为NDRⅢ期者18眼，修正诊断为增殖性糖尿病视网膜病变(proliferative diabetic retinopathy, PDR)Ⅳ期者18眼；PDR 20眼均未行修正诊断。结论：FFA可早期发现糖尿病视网膜病变的微血管异常，更准确对DR进行诊断及分期。
【关键词】 糖尿病；视网膜病变；眼底荧光血管造影
Clinical analysis of fundus fluorescence angiography on diabetic retinopathy
Ping Chen, Wei Zhao, Nan Wang, Hai-Juan Cai, Ke-Hao Zhao
Department of Ophthalmology, Beijing Shijingshan Hospital, Beijing 100043, China
AbstractAIM: To assess the difference between ophthalmoscopy and fundus fluorescence angiography (FFA) in the diagnosis of diabetic retinopathy (DR) and to evaluate the effect of FFA in the diagnosis of DR. METHODS: A total of 120 patients (238 eyes) with diabetes mellitus were examined with ophthalmoscopy and FFA. The differences of diagnosis and classification of DR were analyzed by using the two examination methods. RESULTS: Forty-two eyes had normal fundus under ophthalmoscope, among whom 11 eyes were revised to the nonproliferative diabetic retinopathy (NDR) phaseⅠand 3 eyes were revised to the NDR phaseⅢ by FFA examination. Among the 176 eyes with NDR under ophthalmoscope, 18 eyes were revised to the NDR phase Ⅲ and 18 eyes were revised to the proliferative diabetic retinopathy (PDR) phase Ⅳ by FFA examination. None of the 20 eyes with PDR phase Ⅳ-Ⅵ underwent revisional diagnosis.CONCLUSION: FFA is a an efficient method in early diagnosis and classification of DR.
· KEYWORDS: diabetes mellitus; retinopathy; fundus fluorescence angiography (FFA)
0引言
目前我国糖尿病患者日趋增多，其发病率每年以3%的速度递增[1]。糖尿病视网膜病变（diabetic retinopathy, DR）是其严重并发症之一，也是主要的致盲眼病之一。由于DR具有进行性，不可逆性的特点，早期发现DR微血管异常，控制与减慢DR的发展将有效保存患者中心视力，降低致盲率，提高患者生活质量。眼底荧光血管造影（fundus fluorescence angiography， FFA）对于糖尿病视网膜病变的早期发现，及时治疗有指导意义。我院于2006年对内分泌科确诊为2型糖尿病的120例（238眼）患者行FFA检查，结果分析如下。
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