【摘要】  视网膜缺血再灌注损伤是目前临床上常见的眼病，主要发生于视网膜中央动静脉栓塞、急性闭角性青光眼、糖尿病性视网膜病等视网膜血管阻塞所引起的缺血性眼病。表现为许多缺血性眼病患者在血液再通后，视网膜损伤严重，视功能反而进一步下降。视网膜缺血再灌注损伤是多因素综合作用的结果，主要包括氧自由基的损伤作用，细胞内的钙超载现象,白细胞作用以及细胞凋亡等。本文就国内外有关视网膜缺血再灌注损伤的治疗进展综述如下。

    【关键词】  视网膜缺血再灌注损伤　治疗　进展

    　　Progression in the treatment of retinal ischemia-reperfusion injury

    Cheng Zhao, Zhi-Peng You

    Department of Ophthalmology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China

    AbstractRetinal ischemia-reperfusion injury is a common oculopathy when retinal arteries become occluded in central retinal artery occlusion, acute angle-closure glaucoma or diabetic retinopathy. The resulting ischemia can cause serious retinal damage and descending visual function. Multiple factors cause retinal ischemia-reperfusion injury, including the injury effect of oxygen-derived free radicals, intracellular calcium overload, the action of leucocyte and apoptosis. The present paper reviews the progression in the treatment of retinal ischemia-reperfusion injury.

    · KEYWORDS: retinal ischemia-reperfusion injury; treatment; progression

　　 0前言

    缺血性眼病患者的视网膜在恢复供血后，却出现明显的功能障碍，甚至发生不可逆性损伤，再灌注并不缓解细胞损伤，反而加剧了细胞死亡，这就是临床上的视网膜缺血再灌注（RIR）损伤。其损害学说包括：氧自由基学说、一氧化氮学说、钙通道学说、炎症反应学说、兴奋性氨基酸学说、基因调控学说、细胞凋亡学说等。针对各种学说，国内外关于RIR损伤的治疗研究，也取得了一定的进展，现综述如下。

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