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糖尿病视网膜病变发病机制中VEGF与PEDF的研究进展

http://www.cnophol.com 2008-1-24 17:22:55 中华眼科在线

 

7 Otani A, Takagi H, Suzuma K, Honda Y. Angiontesin Ⅱpotentiates vascular endothelial growth factor-induced angiogenic activity in retinal mirocapillary endothelial cells. Circ Res ,1998;82:619-628

8 Takagi H, Oh H, Otani A, Suzuma K, Suzuma I. Molecular mechanisms of retinal neovascularization in diabetic retinopathy. Inter Congress Series ,2004;1262:160-163

9 Funatsu H,Yamashita H, Nakamura S, Mimura T, Eguchi S, Noma H, Hori S. Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor are related to diabetic macular edema. Ophthalmology ,2006;113(2):294-301

10 Aiello LP, Bursell SE, Clermont A, Duh E, Ishii H, Takagi C, Mori F, Ciulla TA, Ways K, Jirousek M, Smith LE, King GL.Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes ,1997;(46):1473-1480

11 Funatsu H, Yamashita H. Noma H.Risk evaluation of outcome of vitreous surgery for proliferative diabetic retinopathy based on vitreous level of vascular endothelial growth factor and angiotensin Ⅱ. Br J Ophthalmol , 2004;88(8):1064-1068

12 Ishida S,Usui T, Yamashiro K, Kaji Y,Ahmed E,Carrasquillo KG, Amano S, Hida T,Oguchi Y, Adamis AP. VEGF164 is proinflammatory in the diabetic retina. Invest Ophthalmol Vis Sci ,2003;44:2155-2162

13李媛,卢艳.糖尿病视网膜病变早期发病机制研究进展.国际眼科杂志,2005;5(4):750-754

14张小玲,邱曙东,陈艳炯,孙文涛.糖尿病视网膜病变发病机制研究进展.国际眼科杂志,2005;5(6):1239-1241

15 Ogata N, Nishikawa M, Nishimura T, Mitsuma Y, Matsumura M. Unbalance vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am J Ophthalmol ,2002 ;134(3):348-353

16 Ogata N, Tombran-Tink J, Nishikawa M, Nishimura T, Mitsuma Y, Matsumura M. Pigment epithelium-derived factor in the vitreous is low in diabetic retinopathy and high in rhegmatogenous retinal detachment. Am J Ophthalmol ,2001;132(3):378-382

17 Sydorova M, Lee MS. Vascular endothelial growth factor in virtreous and serum of patients with either proliferative diabetic retinopathy or proliferative vitreoretinopathy. Ophthalmic Res ,2005;37(4):188-190

18 Talitha T, Rajah and Paula Grammas. VEGF and VEGF receptor levels in reinal and brain-derived endothelial cells. Biochem Biophy Res Commun ,2002;293:710-713

19 Konopatskaya O, Churchill AJ, Harper SJ, Bates DO, Gardiner TA. VEGF165b, an endogenous C-terminal splice variant of VEGF, inhibits retinal neovascularization in mice. Mol Vis ,2006;26;12:626-632

20 Gettins PG, Simonovic M, Volz K. Pigment epithelium-derived factor (PEDF), a serpin with potent anti-angiogenic and neurite outgrowth-promoting properties. Biol Chem ,2002;383:1677-1682

21 Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W, Bouck NP. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science ,1999;285:245-248

22 Bouck N. PEDF: anti-angiogenic guardian of ocular function. Trends Mol Med ,2002;8:330-334

23 Amano S, Yamagishi S, Inagaki Y, Nakamura K, Takeuchi M, Inoue H, Imaizumi T. Pigment epithelium-derived factor inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes. Microvasc Res ,2005; (69):45-55

24 Matsuoka M, Ogata N, Minamino K, Matsumura M. Expression of pigment epithelium-derived factor ang vascular endothelial growth factor in fibrovascular membranes from patients with proliferative diabetic retinopathy. Jpn J Ophthalmol ,2006;50(2):116-120

25 Boehm BO, Lang G, Feldmann B, Kurkhaus A, Rosinger S, Volpert O, Lang GK, Bouck N. Proliferative diabetic retinopathy is associated with a low level of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor. Horm Mebab Res ,2003;35(6):328-336

26 Yamagushi S, Nakmura K, Matsui T, Inagaki Y, Takenaka K, Jinnouchi Y. Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking endothelial growth factor expression. J Biol Chem ,2006;281(29):20213-20220

27 Duh EJ, Yang HS, Suzuma I, Miyagi M, Youngman E, Moril K, Katai M, Yan L, Suzuma K, West K, Davarya S, Tong P, Gehlbach P, Pearlman J, Crabb JW, Aiello LP, Campochiaro PA, Zack DJ.Pigment Epithelium-Derived Factor Suppresses Ischemia-Induced Retinal Neovascularization and VEGF-Induced Migration and Growth. Invest Ophthalmol Vis Sci ,2002;43:821-829

28 Stellmach V, Crawford SE, Zhou W, Bouck N. Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. Proc Natl Acad Sci USA ,2001;98:2593-2597

29 Mori K, Gehlbach P, Ando A, McVey D, Wei L, Campochiaro PA. Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor. Invest Ophthalmol Vis Sci ,2002;43(7): 2428-2434

30 Wong WT, Rex TS, Auricchio A, Maguire AM, Chung D, Tang W, Bennett J. effect of over-expression of pigment epithelium derived factor on developing retinal vasculature in the mouse. Mol Vis , 2004;10:837-844

31 Zhang SX, Wang JJ, Gao G, Parke K, Ma JX. Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibition VEGF-VEGF receptor 2 binding in diabetic retinopathy. J Mol Endocrinol ,2006;37(1):1-12

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