3 Ang在DR治疗中的展望

     DR早期病理改变为视网膜微血管通透性升高，DR发展到后期，将由NPDR期发展为以视网膜新生血管和纤维化为特征的PDR期，在PDR期视网膜新生血管引起的渗漏对患者的视力影响极大，如果能够有效的抑制视网膜新生血管引起的渗漏必将抑制DR的进一步发展。目前的研究表明，Ang-1具有调节内皮之间、内皮—基质之间相互作用, 促进血管成熟并维持血管结构，在VEGF等生长因子的存在下, 由于其抗凋亡、促内皮迁移的作用, 增强了VEGF的促内皮芽性生长及血管网络形成作用，而Ang-2做为Ang-1的拮抗剂能拮抗Ang-1的这些生物效应。如何在DR的状况下调整Ang/Tie-2信号传导系统各成员的表达及作用，使其在DR早期血管重建，血管稳定，防渗漏中最大程度的发挥有益作用，是一个极有研究价值值得深入研究的问题。

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