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5问题与展望
针对眼部新生血管性疾病的治疗较为困难，尤其是药物治疗较少，因此常常成为视功能丧失的主要原因。近年来，虽然激光、手术及放射治疗等可在一定程度上缓解或阻止新生血管的发生、发展，但是均有不可避免地损害健康组织的风险性，且不同程度地存在疗效欠佳、代价昂贵及复发的弊病，因此寻求特异及有效的药物治疗眼部新生血管一直是广大眼科医师孜孜以求的目标。SDF1/CXCR4的出现为防治眼部新生血管性疾病提供了一个新的靶点。目前，SDF1特异性抗体及CXCR4抑制剂（如AMD3100等[30,31]）已开始应用于糖尿病视网膜病变、血液病、肿瘤、自身免疫性疾病等的治疗，取得较好的疗效，其应用前景广阔。但是目前对SDF1/CXCR4的作用机制了解还不十分清楚，其对新生血管的治疗探索尚处于早期阶段，有待大量研究以进一步证明其安全性和有效性。
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