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葡萄膜炎相关细胞因子与趋化因子基因多态性的研究进展

http://www.cnophol.com 2009-6-23 9:21:26 中华眼科在线

  Severe complications were seen in 8% of cases, which is lower than in other reported studies in the literature; 16.9% by Reddy et al[5] and 24% by Ormerod et al[12]. The rate of healing into a scar was 88%, comparable to 80% in the study by Reddy et al[5]. The evisceration and enucleation rate of 3.5% was comparable to the 2% range reported in another series[12]. Most failures of therapy occurred in patients with advanced ulcers at the time of presentation, either due to existing predisposing conditions or because of late presentation.

  Based on the findings of this study, where contact lens wear is a significant ocular risk factor in the development of corneal ulcers, appropriate education about lens care and hygiene among wearers should be emphasized. They should be advised to seek early and appropriate treatment if eye infection or trauma occurs and to avoid contact lens usage. Medical practitioners should have a higher level of suspicion of corneal infection in this group.

  CONCLUSION

  Contact lens wear is the most common predisposing factor for corneal ulcers, followed by trauma. They mostly occur in the younger population. Ocular surface diseases is an association in the older population and usually results in poorer visual prognosis. Gram negative microbes (68%) were more prevalent than gram positive organisms. Pseudomonas aeruginosa was the most frequently isolated bacteria in every ocular risk factor group.

  【参考文献】

  1 Resnikoff S, Pascolini D, Etyaale D, Kocur I, Pararajasegaram R, Pokharel GP, Mariotti SP. Global data on visual impairment in the year 2002. Bull World Health Organ 2004; 82(11):844855

  2 Zainal M, Ismail SM, Ropilah AR, Elias H, Arumugam G, Alias D, Fathilah J, Lim TO, Ding LM, Goh PP. Prevalence of blindness and low vision in Malaysian population: results from the National Eye Survey 1996. Br J Ophthalmol 2002; 86(9):951956

  3 World Health Organization. Guidelines for the Management of Corneal Ulcer at Primary, Secondary & Tertiary Care health facilities in the SouthEast Asia Region. World Health Organization Regional Office for SouthEast Asia 2004

  4 Morgan PB, Efron N, Brennan NA, Hill EA, Raynor MK, Tullo AB. Risk factors for the development of corneal infiltrative events associated with contact lens wear. Invest Ophthalmol Vis Sci 2005; 46(9):31363143

  5 Reddy SC, Tan BC. Bacterial keratitis in Northeast Peninsula Malaysia: a review of 136 cases. Biomed Res 1999;10:113119

  6 Roberts A, Kaye AE, Kaye RA, Tu K, Kaye SB. Informed consent and medical devices: the case of the contact lens. Br J Ophthalmol 2005;89(6):782783

  7 Bourcier T, Thomas F, Borderie V, Chaumeil C, Laroche L. Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases. Br J Ophthalmol 2003;87(7):834838

  8 Levey SB, Katz HR, Abrams DA, Hirschbein MJ, Marsh MJ. The role of cultures in the management of ulcerative keratitis. Cornea 1997;16(4):383386

  9 Sharma S, Gopalakrishnan S, Aasuri MK, Garg P, Rao GN. Trends in contact lensassociated microbial keratitis in Southern India. Ophthalmology 2003;110(1):138143

  10 Srinivasan M. Fungal keratitis. Curr Opin Ophthalmol 2004;15(4):321327

  11 Smitha S, Lalitha P, Prajna VN, Srinivasan M. Susceptibility trends of pseudomonas species from corneal ulcers. Indian J Med Microbiol 2005;23(3):168171

  12 Ormerod LD, Hertzmark E, Gomez DS, Stabiner RG, Schanzlin DJ, Smith RE. Epidemiology of microbial keratitis in southern California, a multivariate analysis. Ophthalmology 1987;94(10):13221333

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