Bevacizumab（Avastin）对眼科疾病的治疗作用

　　宋徽1,2,任兵2,高晓唯2

　　作者单位：1（832000）中国新疆维吾尔自治区石河子市，石河子大学医学院；2（830011）中国新疆维吾尔自治区乌鲁木齐市，解放军474医院眼科中心

　　作者简介：宋徽，男，石河子大学2006级眼科硕士研究生，研究方向：眼外肌，眼底病。

　　通讯作者：任兵，解放军474医院眼科中心主任，主任医师，教授，研究方向：眼外肌与眼底病. [email protected]

　　收稿日期:2007-10-26修回日期:2008-04-16

　　Effect of bevacizumab (avastin) on eye diseases

　　Hui Song1,2, Bing Ren2, Xiao-Wei Gao2

　　1Graduate School of Medical College, Shihezi University，Shihezi 832003，Sin Kiang Autonomous Region, China;

　　2Department of Ophthalmology, No. 474 Hospital, Ophthalmology Center of Chinese PLA, Urumchi 830011, Sin Kiang Autonomous Region, China

　　Correspondence to: Bing Ren. Department of Ophthalmology, No.474 Hospital, Ophthalmology Center of Chinese PLA, Urumchi 830011, Sin Kiang Autonomous Region, China. [email protected]
 
　　Received:2007-10-26Accepted: 2008-04-16

　　Abstract

　　Bevacizumab is a monoclonal antibody that inhabits the angiogenesis through targeting the vascular endothelial growth factor (VEGF). In ophthalmology, it has a bright future in treating the angiogenesis of the cornea, iris, choroid, retina and the age-related macular degeneration (AMD), macular edema, etc.

　　KEYWORDS: bevacizumab; angiogenesis; treatment
Song H, Ren B, Gao XW. Effect of bevacizumab (avastin) on eye diseases. Int J Ophthalmol(Guoji Yanke Zazhi)2008;8(6):1230-1232

　　摘要

　　贝代单抗(bevacizumab)是近几年出现的重组单克隆抗体，通过抑制血管内皮生长因子（VEGF）达到抑制新生血管生成的作用。在眼科中，对于角膜、虹膜、脉络膜、视网膜的新生血管及年龄相关性黄斑变性、黄斑水肿等疾病的治疗具有很可观的应用前景。

　　关键词：bevacizumab；新生血管；治疗

　　宋徽,任兵,高晓唯. Bevacizumab（Avastin）对眼科疾病的治疗作用.国际眼科杂志 2008;8(6):1230-1232