甲状腺相关眼病组织病理学研究
董凯，何为民，罗清礼
作者单位：（610041）中国四川省成都市，四川大学华西医院眼科
作者简介：董凯，男，住院医师，华西医院眼科硕士研究生。
通讯作者：何为民，女，博士，副教授，硕士生导师[email protected]
收稿日期：2008-01-24修回日期：2008-05-06
Study on histopathology of thyroid-associated ophthalmopathy
Kai Dong, Wei-Min He, Qing-Li Luo
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Correspondence to:Wei-Min He. Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. [email protected]
Received:2008-01-24Accepted:2008-05-06
Abstract
AIM: To study histopathologic characteristics of thyroid-associated ophthalmopathy (TAO).
METHODS: Twenty-one thyroid-associated ophthalmo-pathy cases with typical clinical symptoms and signs were collected, from 2000 to 2005, as experimental group, which underwent HE staining, Massons trichrome stain-ing, and Alcian blue staining. Every case was confirmed by thyroid functions, CT scan, histopathological diagnosis and underwent orbital decompression surgery and strabis-mus surgery.
RESULTS: HE staining indicated inter-adipocytic spaces enlarged, adipose interstitial eosin stained, fiber septal formation and muscle fiber ruptured, fibrogenesis, dissolved, vacuolization. Massons trichrome staining showed muscle and adipose interstitial blue staining, adipose tissue angiogenesis. Adipose interstitial blue staining also could be seen in Alcian blue staining.
CONCLUSION: Inter-adipocytic spaces enlarging, GAG aggregation, fiber septal formation and muscle fiber rupture, fibrogenesis, dissolving, vacuolization, lym-phocytes infiltration compose of histopathologic chara-cteristics of TAO.
KEYWORDS: thyroid-associated ophthalmopathy; histopathology
Dong K, He WM, Luo QL. Study on histopathology of thyroid-associated ophthalmopathy. Int J Ophthalmol(Guoji Yanke Zazhi)2008;8(6):1159-1161
摘要
目的：探讨甲状腺相关眼病组织病理学改变。
方法：收集我院2000/2005经症状﹑体征﹑甲状腺功能和CT证实为甲状腺相关眼病，并行眼眶减压术或复视矫正术的TAO患者共21例，行HE染色，Masson染色和阿辛蓝染色，观察TAO的病理学改变。
结果：HE染色可见脂肪间隙增宽，间质伊红红染，纤维隔形成，肌纤维断裂，纤维化，淡染，部分溶解，空泡形成，Masson染色可见肌肉间质蓝染，脂肪组织血管增多，间质蓝染；阿先蓝染色可见脂肪间质蓝染。
结论：甲状腺相关眼病主要组织病理学改变有脂肪间隙增宽，纤维隔形成，血管新生；肌纤维不同程度肌浆凝集，肌纤维断裂，纤维化，淡染，部分溶解，空泡形成。急性期可见糖胺聚糖沉积，肌束间炎性细胞浸润。
关键词：甲状腺相关眼病；组织病理
董凯，何为民，罗清礼.甲状腺相关眼病组织病理学研究.国际眼科杂志2008;8(6):1159-1161
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