视网膜细胞凋亡与bcl-2基因

　　陈伟，彭秀军

　　作者单位：（100037）中国北京市，海军总医院眼科

　　作者简介：陈伟，男，天津医科大学在读硕士研究生，导师彭秀军教授。

　　通讯作者：彭秀军，男，医学博士，教授，主任医师，享受国务院政府特殊津贴专家，研究方向：白内障，眼外伤等. [email protected]

　　收稿日期：2008-01-22修回日期：2008-05-13

　　poptosis of retinal cells and its modulating gene bcl-2
Wei Chen, Xiu-Jun Peng

　　Department of Ophthalmology, Navy General Hospital of Chinese PLA, Beijing 100037, China

　　Correspondence to: Xiu-Jun Peng. Department of Ophthalmology, Navy General Hospital of Chinese PLA, Beijing 100037, China. [email protected]

　　Received:2008-01-22Accepted: 2008-05-13

　　Abstract

　　In some ocular diseases such as retinal light damage, retinal degenerations, glaucoma, etc, apoptosis plays important role in the death of retinal photorecept or cell, ganglial cells and some other retinal cells, which is the major fact of the visual function loss. Among the proteins coded by the genes of bcl-2 family, bcl-2, bcl-xl, mcl-1, bag-1 and a1 act as death repressors, whereas bax, bak, bcl-Xs, bik and bad promote cell death. These different functions were shown to be mediated by homodimerzation/heterodimerization of the various family members. Therefore, a critical balance between molecules above may determine the fate of cells in response to apoptosis-inducing conditions. We focused on the changes of Bcl-2 expression and its related mechanism in some ocular diseases which companions apoptosis of retinal cells.  

　　KEYWORDS: apoptosis; retina; bcl-2
Chen W, Peng XJ. Apoptosis of retinal cells and its modulating gene bcl-2. Int J Ophthalmol(Guoji Yanke Zazhi)2008;8(6):1236-1238

　　摘要

　　细胞凋亡与视网膜光损伤、视网膜变性、青光眼等多种眼病中视网膜光感受器细胞、神经节细胞等的死亡有密切关系，是视功能丧失的主要原因。凋亡调控基因bcl-2家族成员可分为凋亡阻遏基因（bcl-2、bcl-XL、mcl-1、bag-1、a1 等）和凋亡促进基因（bax、bak、bcl-Xs、bik、bad等），这些基因编码的蛋白质分子通过组成和/或影响同二聚体与异二聚体的不同比例而介导其对细胞存活的生物学效应。本文就一些伴有视网膜细胞凋亡的常见眼病所致bcl-2基因表达的变化及其相关机制作一综述。
 
　　关键词：凋亡；视网膜；bcl-2基因家族

　　陈伟,彭秀军.视网膜细胞凋亡与bcl-2基因.国际眼科杂志 2008;8(6):1236-1238