Xu guoxing   Xie Maosong   Wu Yabing

福建医科大学附属第一医院   350005

Objective： To indicate the difference of ultramicrostructure between the tPVR treated with GM6001 and without GM6001.To evaluate the interventional effect of GM6001 in tPVR course.
Method: 180 SD rats were divided randomly into three groups：the control group，the tPVR group，the tPVR treated with GM6001group.The ultramicrostructure of the retina was revealed by the transmission electron microscope.

Results:The transmission electron microscope showed that the retinal photorecepter cells，the retinal pigment epithelium and the retina inner and outer barriers were damaged in the tPVR group.In the tPVR treated with GM6001group，the membranous discs of the outer segment of the retinal photorecepter cells were still clear.There were plenty of chondriosome，pinocytosis bullules and smooth endoplasmic reticulum in the cytoplasm，while some of the cristae in the chondriosome were lost.The cell junction was clear and regular.The plasma membrane infoldings of the basilar part of the retinal pigment epithelium in the tPVR treated with GM6001 group were more than that in the tPVR group.

Conclusion:GM6001 playes an important role in interfering the course of tPVR by protecting the ultramicrostructure of the retina.