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5展望
角膜创伤愈合是一个复杂的过程，这个复杂过程离不开多种生物因子，细胞外基质蛋白及酶的参与。因为与修复相关的生物因子和酶数量众多，因此传统的临床前和临床研究中仅针对其中某一种或几种进行干预，往往达不到预期目的。但现在发现，虽然生物因子数量众多，但进入细胞内的信息通道却为数较少，如能对其中关键的信号通路进行有效阻断和调节，这对于角膜创伤的组织修复和愈合具有目标明确、效果明显的优势。p38 MAPK通路是参与角膜创伤愈合和炎症反应调控的重要信号系统，若能运用特异性药物，在信号通路水平有效地调控p38 MAPK的表达和活性，将为临床角膜创伤和炎症的防治及合理用药提供新的理论依据。
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