青光眼             3291                                      PO0554

　　Limbal Stem Cell Deficiency Following Subconjunctival Mitomycin C Injection for Trabeculectomy

　　Gangolf Sauder, MD, and Jost B. Jonas MD
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the University Heidelberg, Germany

　　Purpose. To report on severe limbus cell insufficiency following trabeculectomy with subconjunctival injection of mitomycin C (MMC).

　　Design. Interventional small case-series.

　　Methods. Seven consecutive Caucasian patients (7 eyes) underwent penetrating trabeculectomy including subconjunctival injection of 0.1 to 0.2 ml of mitomycin C (0,2 mg/mL) at the 12 o’clock position.

　　Results. All patients with a follow-up longer than 1.5 years (n=3 (43%) eyes) developed marked ocular surface problems including corneal thinning (n=1) and scleral melting (n=2). Four (57%) patients with a follow-up shorter than 14 months did not show complications attributable to the subconjunctival application of mitomycin.

　　Conclusions. Since limbal stem cell deficiency may be a late complication of subconjunctival mitomycin C injection, subconjunctival injection of mitomycin C may be avoided in routine antiglaucomatous filtering surgery.

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