【摘要】  　　系统性微血管病变和糖尿病视网膜病变（diabetic retinopathy，DRP）是糖尿病患者致死性及致盲性的根源，然而其具体机制尚不十分清楚。推测免疫和炎症反应可能涉及其病程及病理进展，尤其对于增殖性视网膜病变（perliferative diabetic retinopathy,PDR），因而有人提出DRP是一种炎症性疾病。本文就炎症反应最具代表性的细胞因子之一——肿瘤坏死因子（tumor necrosis factor, TNF）及其在糖尿病视网膜病变中的可能作用加以综述。

【关键词】  糖尿病视网膜病变　肿瘤坏死因子

　　Tumor necrosis factor and diabetic retinopathy

    Wen-Min Jiang, Luo-Sheng Tang

    Department of Ophthamology, the Second Xiangya Hospital of Central-South University, Changsha 410011, Hunan Province, China

    AbstractSystemic microvascular disease and diabetic retinopathy (DRP) are currently the principal causes of morbidity and mortality in patients with diabetes mellitus, yet the mechanism behind it has not been fully understood. It has been demonstrated that immune phenomena and inflammatory reactions might be involved in the pathogenesis and progression, especially in proliferative DRP. Therefore it has been indicating that DRP is an inflammatory disease. The present paper reviews one of the most representative cell factors, tumor necrosis factor (TNF) and its functions in DRP.

    · KEYWORDS: diabetic retinopathy; tumor necrosis factor

　　0引言

    糖尿病视网膜病变发病机制复杂，目前从糖尿病动物模型上对其发病机制在代谢方面、神经元及神经胶质细胞、血液流变学和血管生长因子方面均有所研究。现有观点认为[1]，糖尿病视网膜病变机制中包括了慢性长程炎症反应，炎症与免疫反应贯穿糖尿病视网膜病变的全过程。有人提出DRP是一种炎症性疾病[2]。肿瘤坏死因子（tumor necrosis factor,TNF）就是炎症反应中最具代表性的细胞因子之一。

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