作者：陈青山 魏淳
单位：陈青山(西安市第四医院眼科(西安710004)；魏 淳(陕西中医学院附属医院眼科)
关键词：实验性高眼压；中药；兔
摘要 目的：观察青光眼Ⅱ号对兔实验性高眼压的降眼压作用。方法：实验性家兔分为青光眼Ⅱ号治疗组、正常组和对照组。治疗组和对照组用1%甲基纤维素少量多次注入家兔前房形成实验性高眼压。正常组和对照组用生理盐水灌胃，治疗组用青光眼Ⅱ号灌胃，并观察各组眼压变化。结果：治疗组实验后第5天眼压（2.54±0.45）kPa与实验前相比无显著性差异(P＞0.05),但明显低于对照组眼压(4.05±0.66）kPa，(P＜0.01)。结论：青光眼Ⅱ号具有降低实验性兔高眼压的作用。
Effect of qingguangyanⅡ on experimental ocular hypertension in the rabbits Cheng Qingshan, Wei Chun. Department of Ophthalmoloyy, the Fourth Hospital of Xian, Xian 710004
Key words experimental ocular hypertension traditional Chinese medicine rabbit
Abstract OBJECTIVE: To observe effects of qingguangyanⅡ(青光眼Ⅱ号) on reduction of intraocular pressure ( IOP ) in the experimental rabbits.METHODS: The experimental rabbits were divided into the treated group with qingguangyanⅡ, normal group, and control group. Ocular hypertension was formed with injecting 1% methylcellulose into anterior chamber repeatedly. The rabbits were fed normal saline into stomachs in the normal group and controll group, and qingguangyanⅡin the treated group. The IOP of each group was determined.RESULTS: After five days the intraocular pressure（2.54±0.45）kPa of treated group was compared with before the experiment, and there was not statistical different ( P＞0.05 ). But this IOP ( 4.05±0.66)kPa，was significantly lower than the control group ( P＜0.01 ).CONCLUSION: QingguangyanⅡ could be effect on reduction of IOP in ocular hypertension of the experimental rabbits.
高眼压、视野缺损和视神经损害并列为青光眼三大体征。视神经损害是最重要的病理改变〔1〕，而高眼压是造成视神经损害最危险的因素之一。为了探讨中药的降眼压作用，1996年9月～10月我们观察了中药青光眼Ⅱ号对兔实验性高眼压的影响，报告如下。
1 材料与方法
1.1 实验材料
实验动物：健康家兔18只，体重2.5～3kg，雌雄不拘，由西安医科大学实验动物中心提供，实验前检查眼前节及眼底，选用无眼病者。
药品及试剂：青光眼Ⅱ号方由川芎、香附、丹参、当归、陈皮、苦参、茯苓、夏枯草、车前子、枸杞子、菟丝子、石菖蒲组成。上述药物每味各15g，加水浸泡半小时，分煎3次，去渣取汁，并浓缩成每ml含生药1g。
1%甲基纤维素的制备：取1g甲基纤维素(英国产，上海试剂站分装)加入煮沸的注射用林格氏液30ml中，冷却后再加入注射用林格氏液70ml，高压消毒灭菌备用。
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