¡¡¡¡Early in the 1980s, it was suggested that corticosteroids could damage the RPE barrier and predispose a patient to serous retinal detachments [24]. In most cases, there is leakage of fluoresceinª²stained fluid from one or more small lesions in the RPE. FA demonstrates that choroidal vascular leakage is associated with histologically irregular, narrow choroidal arterioles and choriocapillaris, hypertrophy of Bruch¬ðs membrane, and loss or degeneration of the overlying RPE [25,26]. It can be inferred that increased plasma cortisol concentrations might alter the permeability of the choriocapillaris in one or more focal area in the posterior fundus so that large proteins gain entrance to the RPE and subretinal space, causing leakage of fluid into the subretinal space. Moreover, abnormal choroid vessels may cause RPE damage and incapacitation.

¡¡¡¡CONCLUSION

¡¡¡¡It has been known for a long time that psychological stress is associated with CSC, but the exact cause was not clear. The hypotheses of this paper provide a possible pathophysiology mechanism for CSC induced by psychological stress. We hope that this will provide useful information for further research and the development of treatment for CSC.

¡¾²Î¿¼ÎÄÏס¿
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