4　NO参与视网膜神经节细胞凋亡

　　Monard和Bonne研究认为青光眼视功能的损害是由于视网膜神经节细胞凋亡所致。节细胞的凋亡是在谷氨酰激活N-甲基-D-天冬氨酸(NMDA)膜受体后诱导的，NMDA受体激活产生自由基超氧阴离子和大量的NO，二者结合生成有毒性的化合物OONO-，后者触发节细胞凋亡［3］。

　　作者单位：刘国军（青岛大学医学院附属医院眼科　266003)

　　仇宜解（青岛大学医学院附属医院眼科　266003）

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