Abstract ·AlM : T0 investigate the m echanism Of prOIiferatione什ect induced bv (R,R)一XY一10 and (S.S)一XY一10 onretinal pigmented epitheIial cells(ARPE一19). ·METHODS:Human retinaI pigmented epithelial cells(ARPE一19)and human umbilical vein endOtheIial cells f HUVECs)were used to investigate the e仟ect 0f (R,R)一XY一1 0and (S,S)一XY一10 on cell growth,and their mechanisms ofprOIiferative actiOn by using ERK、 AKT、PI3K、PrOteinkinase C(PKC)and Nit ric oxide svnthase(NOS)inhibit0rs
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