Abstract
·AIM ：T0 investigate the effects of naringenin on laser—jnduced experimental choroidal ne0vascuIarizatjon(CNV)
in rat models．ocular blood flow in rabbit eyes and retinaIfunction recovery after ischemic insults in rat eyes．
·M ETHODS：Male Brown Norway rats were treated tobreak the Bruch s membrane．Naringenin 10g／L(20mg／kg)was given once—daily through intraDerit0neal injection for 4weeks after Iaser treatment．The development of CNV wasdetermined by fluorescein angiography(FA) performedon weeks 2 and 4．The colored microsphere technique andelectroretinography method were used for the study ofocular blood flow and retinaI function recovery．
respectively．
· RESULTS： The choroidaI blood flow in elevatedintraocular pressure (1OP)rabbit eyes was significantly
increased by 10g／L naringenin solution as compared tocontrol group(P<0．05)．The retinal function recovery
after ischemic insults jn rat eyes indicated significantincrease of b—wave recovery in treated group， ascompared to control group(P <0．05)．The intensity offluorescein leakage fr0m the phOt0cOaguIated lesionsdecreased significantly in treated group，com pared to thecontrol group(75．8％一95．0％ ，P<0．01)．

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