A meta-analysis of topical prostaglandin analogues in the treatment of chronic angle-closure glaucoma

　　程金伟 魏锐利

　　第二军医大学附属长征医院眼科 200003

　　Objective：To evaluate the intraocular pressure(IOP)lowering efficacy of prostaglandin analogues topical medications in patients with chronic angle closure glaucoma(CACG).

　　Method:Randomized clinical trials involving CACG patients treated with latanoprost，bimatoprost or travoprost monotherapy were selected.The pooled effects were calculated using DerSimonian and Laird method.

　　Results:Nine randomized clinical trials enrolling a total of 1090 patients were included in the meta-analysis.Relative IOP reduction were diurnal curve，31%，peak，34%，and trough 31%for latanoprost;diurnal curve，26%，peak，28%，and trough 27%for bimatoprost;diurnal curve，28%，peak，32%，and trough 31%for travoprost;diurnal curve，23%，peak，24%，and trough 21%for timolol.

　　Conclusions:Latanoprost travoprost，bimatoprost，and timolol can significantly lower IOP in CACG patients.