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  当前位置: 中华眼科在线 >> 医学频道 >> 临床药学 >> 临床研究 切换到繁體中文 用户登录 新用户注册
Pegaptanib治疗湿性年龄相关性黄斑变性临床研究

http://www.cnophol.com 2008-12-23 10:25:28 中华眼科在线

    4小结

     尽管目前临床上治疗以AMD为代表的CNV相关性疾病的疗法有许多,但由于VEGF在新生血管形成中具有的关键作用,针对VEGF的抑制疗法将可能会成为一种更加科学有效的治疗途径[26-28]。作为第一种应用于眼科临床的VEGF抑制剂,临床试验的结果已初步显示出Pegaptanib治疗眼底新生血管性疾病的优越性。随着对CNV发生机制的深入研究,针对CNV病因进行的治疗将有助于保持和改善患者的视力,提高生活质量,为预防和治愈AMD及其他CNV相关疾病带来新的希望。

   【参考文献】

1 Ambat J, Ambati BK, Yoo SH, Lanchulev S, Adamis AP. Age-related macular degeneration:etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol ,2003;48(3):257-293

2 Ferris FL, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol ,1984;102:1640-1642

3 Witmer AN, Vrensen GF, Van Noorden CJ, Schlingemann RO. Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res ,2003;22(1):1-29

4 Macugen(pegaptanib sodium)[package insert]. New York:Eyetech Pharmaceuticals,Inc,and Pfizer Inc;2004;1-9

5 Ruckman J, Green LS, Beeson J, Waugh S, Gillette WL, Henninger DD, Claesson-Welsh L, Janjic N. 2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain. 1998;273(32):20556-20567

6 White RR, Sullenger BA, Rusconi CP. Developing aptamers into therapeutics. J Clin Invest ,2000;106(8):929-934

7 Bell C, Lynam E, Landfair DJ, Janjic N, Wiles N, Wiles ME. Oligonucleotide NX1838 inhibits VEGF165-mediated cellular responses in vitro . In Vitro Cell Dev Biol Anim ,1999;35(9):533-542

8 Ishida S, Usui T, Yamashiro K, Kaji Y, Amano S, Ogura Y, Hida T, Oguchi Y, Ambati J, Miller JW, Gragoudas ES, Ng YS, D'Amore PA, Shima DT, Adamis AP. VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med ,2003;198(3):483-489

9 Tucker CE, Chen LS, Judkins MB, Farmer JA, Gill SC, Drolet DW. Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys. J Chromatogr B Biomed Sci Appl ,1999;732(1):203-212

10 Drolet DW, Nelson J, Tucker CE, Zack PM, Nixon K, Bolin R, Judkins MB, Farmer JA, Wolf JL, Gill SC, Bendele RA. Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys. Pharm Res ,2000;17(12):1503-1510

11 Vinores SA. Technology evaluation: pegaptanib, Eyetech/Pfizer,2003;5(6):673-679

12 Kourlas H, Schiller DS. Pegaptanib sodium for the treatment of neovascular age-related macular degeneration: a review. Clin Ther ,2006;28(1):36-44

13 Eyetech Study Group. Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina ,2002;22(2):143-152

14 Ju M, Wing J, Samuelsson A, Robinson G, Mailhos C. Macugen Efficacy Study in Corneal Neovascularization Model. Invest Ophthalmol Vis Sci ,2005;46:3025

15 Capone A, Macugen AMD Study Group. Intravitreous Pegaptanib Sodium (MacugenTM) in Patients With Age-Related Macular Degeneration (AMD): Safety and Pharmacokinetics. Invest Ophthalmol Vis Sci ,2005;46:2362

16 Eyetech Study Group. Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: phase II study results. Ophthalmology ,2003;110(5):979-986

17 Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials--TAP report. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group. Arch Ophthalmol ,1999;117:1329-1345

18 Grgoudas ES, Adamis AP, Cunningham ET Jr, Feinsod M, Guyer DR; VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group. Pegaptanib for neovascular age-related macular degeneration. N Engl J Med , 2004;351(27):2805-2816

19 Gryziewicz L. Regulatory aspects of drug approval for macular degeneration. Adv Drug Deliv Rev ,2005;57(14): 2092-2098

20 Siddiqui MA, Keating GM. Pegaptanib: in exudative age-related macular degeneration. Drugs ,2005;65(11):1571-1577

21 Gragoudas ES. VEGF Inhibition Study in Ocular Neovascularization-1 (VISION-1): Efficacy Results From Phase II/III MacugenTM (Pegaptanib Sodium) Clinical Trials . Invest Ophthalmol Vis Sci ,2004;45:2364

22 D'Amico DJ, Bird AC. VEGF Inhibition Study in Ocular Neovascularization-1 (VISION-1): Safety Evaluation From the Pivotal MacugenTM (Pegaptanib Sodium) Clinical Trials. Invest Ophthalmol Vis Sci ,2004;45:2363

23 D'Amico DJ, VEGF Inhibition Study in Ocular Neovascularization(VISION) Clinical Trial Group. VEGF Inhibition Study in Ocular Neovascularization (VISION): Second Year Efficacy Data. Invest Ophthalmol Vis Sci ,2005;46:2309

24 Mieler W, VEGF Inhibition Study in Ocular Neovascularization(VISION) Clinical Trial Group. Safety Evaluation of Second Year Treatment of Age-Related Macular Degeneration With Pegaptanib Sodium (MacugenTM): VEGF Inhibition Study in Ocular Neovascularization (VISION). Invest Ophthalmol Vis Sci ,2005;46:1380

25 Gonzales CR, VEGF Inhibition Study in Ocular Neovascularization (VISION) Clinical Trial Group. Enhanced efficacy associated with early treatment of neovascular age-related macular degeneration with pegaptanib sodium: an exploratory analysis. Retina ,2005;25(7):815-827

26王雨生,朱洁.脉络膜新生血管性疾病的治疗现状.第四军医大学学报,2006;27(6):481-483

27杨秀梅,王雨生,惠延年.内源性脉络膜新生血管抑制因子的研究进展.国际眼科杂志,2004;4(2):307-311

28张鹏,王雨生,胡丹,吴玉丽,罗亚娟,韩泉洪,惠延年.年龄相关性黄斑变性黄斑部循环改变与脉络膜新生血管形成.国际眼科杂志,2003;3(4):43-45

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