作者:章玲,张昱,冯雅莉,卢韦,盛迅伦 作者单位:266555)中国山东省青岛市,青岛经济开发区第一人民医院眼科
【摘要】 目的:分析内源性真菌性眼内炎的临床特征及误诊原因。
【关键词】 内源性眼内炎;真菌;误诊
Clinical analysis of endogenous fungal endophthalmitis Ling Zhang, Yu Zhang, YaLi Feng, Wei Lu,XunLun Sheng Department of Ophthalmology,the First People’s Hospital of Economic Development Zone,Qingdao 266555,Shandong Province, China Abstract AIM: To investigate the clinical characteristics of endogenous fungal endophthalmitis and the reason of misdiagnosis.
METHODS: Three patients received routine ophthalmologic examination and laboratorial examination. After the diagnosis of endogenous fungal endophthalmitis, all patients were treated with medication, of which one patient received surgical treatment.
RESULTS: All the three patients had endogenous infection inducement of mycotic endophthalmitis.Two patients were misdiagnosed as uveitis, and one as chorioretinitis. The vision acuities were improved in two patients after early and active treatment.
CONCLUSION: Endogenous fungal endophthalmitis is often neglected and misdiagnosed. Early diagnosis and treatment can improve the cure rate and keep the visual function
KEYWORDS: endogenous endophthalmitis; fungus; misdiagnosis
方法:3例患者根据病情、病史进行了眼科常规检查及实验室有关检查,确诊后进行药物治疗,其中1例进行手术治疗。
结果:3例均存在内源性真菌性眼内炎感染诱因。2例患者误诊为葡萄膜炎,1例患者误诊为视网膜脉络膜炎。2例通过早期积极治疗后,视力均有不同程度的提高。
结论:内源性真菌性眼内炎发病隐匿,进展缓慢,非常容易被忽视并误诊,详细询问病史和合理的检查对其诊断有着重要的帮助。早期积极有效的治疗,可以高治愈率和保存视功能。
0引言 除了眼部外伤和手术后真菌可以直接导致外源性眼部真菌感染外,非眼部因素也可引起真菌性眼内感染,称为内源性真菌性眼内炎。内源性真菌性眼内炎有逐年增多的趋势,文献报道50%以上内源性眼内炎是由真菌引起[1],这与真菌不易被吞噬杀死及临床上滥用抗生素和皮质类固醇有关,前者可造成菌群失调,后者可能引起机体免疫力下降。其早期诊断和治疗比较棘手,此病可严重危害视功能。我院于200204/200612收治3例内源性真菌性眼内炎,根据发病的特点,采取相应检查,明确诊断。现报告如下。
1临床资料 本组3例患者,男2例,女1例;年龄42~64岁。3例均做前房穿刺玻璃体涂片及细菌培养加药敏试验。3例均先行药物治疗,其中1例药物治疗无效,采用手术治疗。典型病例临床资料见表1。
2结果 病原菌检查:直接涂片及细菌培养均阳性2例,1例为镰刀菌,1例为白色念珠菌;直接涂片阴性而细菌培养阳性1例:为白色念珠菌。预后:3例患者中2例通过药物治疗,视力均有不同程度的提高(例1随访6mo,视力0.8;例2随访10mo,视力0.3)。1例因严重感染行患眼眼内容物摘除术。
[1] [2] 下一页 |