¡¡¡¡7 Barber AJ, Antonetti DA, Gardner TW. Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes: the Penn State Retina Research Group. Invest Ophthalmol Vis Sci 2000(1);41:3561ª²3568

¡¡¡¡8 Behl Y, Krothapalli P, Desta T, DiPiazza A, Roy S, Graves DT. Diabetesª²Enhanced Tumor Necrosis Factorª²¦Á Production Promotes Apoptosis and the Loss of Retinal Microvascular Cells in Type 1 and Type 2 Models of Diabetic Retinopathy. American Journal of Pathology 2008;172(5):1411ª²1418

¡¡¡¡9 Park SH, Park JW, Park SJ, Kim KY, Chung JW, Chun MH, Oh SJ. Apoptotic death of photoreceptors in the streptozotocinª²induced diabetic rat retina. Diabetologia 2003;46(9):1260ª²1268

¡¡¡¡10 Krady JK, Basu A, Allen CM, Xu Y, LaNoue KF, Gardner TW, Levison SW. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspaseª²3 activation in a rodent model of diabetic retinopathy. Diabetes 2005;54(5):1559ª²1565

¡¡¡¡11 Liu H, Yang R , Tinner B, Choudhry A, Schutze N, Chaqour B. Cysteineª²rich protein 61 and connective tissue growth factor induce deadhesion and anoikis of retinal pericytes. Endocrinology 2008;149(4):1666ª²1677

¡¡¡¡12 Van Setten G, Berglin L, Blalock TD , Schultz G.. Detection of connective tissue growth factor in subretinal fluid following retinal detachment: possible contribution to subretinal scar formation, preliminary results. Ophthalmic Res 2005;37(6):289ª²292

¡¡¡¡13 Zhou XD, Xiong MM, Tan FK, Guo XJ, Arnett FC. SPARC, An upstream regulator of connective tissue growth factor in response to transforming growth factor ¦Â stimulation. Arthritis & Rheumatism 2006;54(12)£º3885ª²3889

¡¡¡¡14 Zhou X, Tan FK, Guo X , Wallis D, Milewicz DM, Xue S, Arnett FC. Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor in cultured normal human fibroblasts. Arthritis Rheum 2005; 52(1):257ª²261

¡¡¡¡15 Aranda J, Rivera JC, Jeziorski MC, Riesgoª²Escovar J, Nava G, L pezª²Barrera F, Quir zª²Mercado H, Berger P, Mart nez de la Escalera G, Clapp C. Rivera. Prolactins Are Natural Inhibitors of Angiogenesis in the Retina. Invest Ophthalmol Vis Sci 2005;46(8):2947ª²2953

¡¡¡¡16 Reich SJ, Fosnot J, Kuroki A, Tang W, Yang X, Maguire AM, Bennett J, Tolentino MJ. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol Vis 2003;9(5):210ª²216

¡¡¡¡17 Kim B, Tang Q, Biswas PS, Xu J, Schiffelers RM, Xie FY, Ansari AM, Scaria PV, Woodle MC, Lu P, Rouse BT. Inhibition of Ocular Angiogenesis by siRNA Targeting Vascular Endothelial Growth Factor Pathway Genes: Therapeutic Strategy for Herpetic Stromal Keratitis. American Journal of Pathology 2004;165(6):2177ª²2185

¡¡¡¡18 Twigg SM, Cooper ME. The time has come to target connective tissue growth factor in diabetic complications. Diabetologia 2004;47(6):965ª²968

¡¡¡¡19 Gaucher D, Chiappore JA, P ques M, Simonutti M, Boitard C, Sahel JA, Massin P, Picaud S. Microglial changes occur without neural cell death in diabetic retinopathy. Vision Res 2007;47(5):612ª²623

¡¡¡¡20 Gastinger MJ, Singh RS, Barber AJ. Loss of cholinergic and dopaminergic amacrine cells in streptozotocinª²diabetic rat and Ins2Akitaª²diabetic mouse retinas. Invest Ophthalmol Vis Sci 2006 ;47(7):3143ª²3150

¡¡¡¡21 Varkonyi TT, Peto T, Degi R, Lengyel C, Jan ky M, Kempler P, Lonovics J. Impairment of visual evoked potentials: an early central manifestation of diabetic neuropathy? Diabetes Care 2002;25(9):1661ª²1662

¡¡¡¡22 Ozdek S, Lonneville YH, Onol M, Yetkin I, Hasanreisolu BB. Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry. Eye 2002;16(6):761ª²765

¡¡¡¡23 Han Y, Bearse MA Jr, Schneck ME, Barez S, Jacobsen CH, Adams AJ. Multifocal electroretinogram delays predict sites of subsequent diabetic retinopathy. Invest Ophthalmol Vis Sci 2004;45(3):948ª²954

¡¡¡¡24 Tikellis C, Cooper ME, Twigg SM. Connective tissue growth factor is upª²regulated in the diabetic retina: amelioration by angiotensinª²converting enzyme inhibition. Endocrinology 2004;145(2): 860ª²866

¡¡¡¡25 Kuiper EJ, Witmer AN, Klaassen I, Oliver N, Goldschmeding R, Schlingemann RO. Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina. Br J Ophthalmol 2004;88(8):1082ª²1087

¡¡¡¡26 Suzuma K, Naruse K, Suzuma I, Takahara N, Ueki K, Aiello LP, King GL. Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3ª²kinaseª²aktª²dependent pathways in retinal vascular cells. J Biol Chem 2000;275(52):40725ª²40731

¡¡¡¡27 Lorenzi M, Gerhardinger C. Early cellular and molecular changes induced by diabetes in the retina. Diabetologia 2001;44(7):791ª²804

¡¡¡¡28 Hishikawa K, Nakaki T, Fujii T. Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells. Eur J Pharmacol 2000;392(1ª²2):19ª²22

¡¡¡¡29 Liu H, Yang R, Tinner B, Choudhry A, Schutze N, Chaqour B. Cysteineª²rich protein 61 and connective tissue growth factor induce deadhesion and anoikis of retinal pericytes. Endocrinology 2008;149(4):1666ª²1677

¡¡¡¡30 Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Levison SW. Diabetic retinopathy: more than meets the eye. Surv Ophthalmol 2002;47(suppl 2):S253ª²S262

¡¡¡¡31 Layton CJ, Chidlow G, Casson RJ Wood JP, Graham M, Osborne NN.Monocarboxylate transporter expression remains unchanged during the development of diabetic retinal neuropathy in the rat. Invest Ophthalmol Vis Sci 2005;46(8):2878ª²2885

¡¡¡¡32 Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry 2003;27(2):283ª²290

¡¡¡¡33 Joussen AM, Poulaki V, Mitsiades N, Cai WY, Suzuma I, Pak J, Ju ST, Rook SL, Esser P, Mitsiades CS, Kirchhof B, Adamis AP, Aiello LP. Suppression of Fasª²FasLª²induced endothelial cell apoptosis prevents diabetic bloodª²retinal barrier breakdown in a model of streptozotocinª²induced diabetes. FASEB J 2003;17(1):76ª²78

¡¡¡¡34 Shimo T, Nakanishi T, Nishida T, Asano M, Sasaki A, Kanyama M, Kuboki T, Matsumura T, Takigawa M. Involvement of CTGF, a hypertrophic chondrocyteª²specific gene product, in tumor angiogenesis. Oncology 2001;61(4):315ª²322

¡¡¡¡35 Cooper ME, Bonnet F, Oldfield M, Jandeleitª²Dahm K. Mechanisms of diabetic vasculopathy: an overview. Am J Hypertens 2001;14(5):475ª²486

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