作者： Grosskreutz CL,Qu J,Wang D

　　出处：Experimental eye research.2010-07;91(1):48-53.

　　文献类型：综述 PUBMED链接：PMID 20394744

　　Abstract：Glaucoma is a disease in which retinal ganglion cells (RGCs) die leading ultimately to bli... Glaucoma is a disease in which retinal ganglion cells (RGCs) die leading ultimately to blindness. Over the past decade and a half, information has begun to emerge regarding specific molecular responses of the retina to conditions of elevated intraocular pressure (IOP). It is now clear that the state of the RGC in glaucoma depends on a balance of pro-survival and pro-death pathways in the retina and details of these responses are still being worked out. In this review, we will discuss the evidence supporting the involvement of specific apoptotic cascades as well as the insults that trigger RGC apoptosis. In addition, we will present evidence supporting the existence of endogenous protective mechanisms as well as exogenous neuroprotective strategies.

　　中文摘要：

　　青光眼是因视网膜神经节细胞(RGCs)死亡最终导致失明的疾病。15年来，学者提出了视网膜对升高的眼压产生特殊分子反应的理论。现在已经明确，青光眼RGC的状况取决于视网膜中促生存和促死亡通路的平衡，这些反应的细节仍在研究中。本文中，我们将讨论支持特殊凋亡级联的相关证据和激发RGC凋亡的刺激因素，并且给出支持内源性保护机制的存在和外源性神经保护策略的证据。