【摘要】  眼底新生血管是多种眼病的并发症，研究发现促进眼底新生血管发生发展的最主要的因子是血管内皮生长因子,在这些眼病的病理过程中血管内皮生长因子表达上调，表达上调的血管内皮生长因子引起脉络膜或视网膜的新生血管。目前缺少针对眼底新生血管的有效的早期治疗手段，一系列下调或阻断血管内皮生长因子或其受体的药物和抑制二者结合后生物学效应发挥的药物已成为治疗眼底新生血管研究的热点之一。

【关键词】  血管内皮生长因子；血管内皮生长因子受体；眼底新生血管

     Vascular endothelial growth factor and its receptors in choroid and retinal neovascularization

    Hong-Wei Zhou, Qiang Wu

    Foundation item: "Climbing Mountain" Project of Science and Technology Commission of Shanghai Municipality, China (No.064119543)

    Department of Ophthalmology, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China

    Abstract Choroid and retinal neovascularization are the complications of several types of ophthalmopathy, and current researches discover that the most important enhancing factor of choroid and retinal neovascularization is vascular endothelial growth factor (VEGF). The expression of VEGF is up-regulated in these diseases, and up-regulated VEGF can induce choroid and retinal neovascularization. At present effective early treatment method of choroid and retinal neovascularization is deficiency. One of the focuses in treating choroid and retinal neovascularization is researches on drugs which can either down-regulate or block VEGF as well as its receptors, or suppress the biological effects of VEGF after binding to its receptors.

    · KEYWORDS: vascular endothelial growth factor; vascular endothelial growth factor receptor; choroid and retinal neovascularization

    0引言

    眼底新生血管是多种眼病的严重并发症，如糖尿病视网膜病变（diabetic retinopathy DR）、早产儿视网膜病( retinopathy of prematurity ROP)、年龄相关性黄斑病变( age-related macular degeneration AMD)等，严重影响视力，甚至致盲。血管内皮生长因子(vascular endothelial growth factor VEGF)也曾被称为VPF（vascular permeability factor）和VAS(vaculotropin)，是调节血管功能、促进新生血管的重要因子，在肿瘤生长、糖尿病视网膜病变、创伤愈合等方面一直得到广泛的研究。随着社会的发展和人民生活水平的提高，眼底新生血管疾病也越来越受到重视，针对血管内皮生长因子的研究进展迅速，因而有必要进一步对血管内皮生长因子及其受体与眼底新生血管的相关领域进行探讨,以利于对该方面进展的了解和前沿性研究。

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