Ketorolac tromethamine 0.4% ophthalmic solution may be a useful adjunct for improving patient comfort and treatment compliance during the induction phase of dry eye therapy with cyclosporine 0.05% ophthalmic emulsion (Restasis, Allergan), Barry A. Schechter, MD, said to colleagues at the annual meeting of the Association for Research in Vision and Ophthalmology here.

　　在0.05%环孢霉素A眼用乳剂（Restasis, Allergan）治疗干眼症的诱导期，加用0.4%酮咯酸氨丁三醇，可使患者舒适度提高，依从性更好，Barry A. Schechter, MD在视觉与眼科学研究协会的年会上说。

　　Dr. Schechter reported the results of a 6 week, open-label pilot study in which 52 patients were randomly assigned to twice-a-day treatment with cyclosporine alone or with concurrent use of ketorolac administered 10 minutes prior to the cyclosporine. At evaluations performed 2 and 6 weeks after treatment, patients using ketorolac experienced greater improvements in ocular comfort and corneal staining.

　　Dr. Schechter介绍了一项为期6周、非盲性试验研究，共52名患者，随机分为两组，一组只以环孢霉素A治疗，每天两次，另一组在每次点滴环孢霉素A前10分钟，点酮咯酸一次。治疗后2周和6周，分别检查评价，加用酮咯酸的患者无论是眼部舒适还是角膜染色方面，都明显好于另一组。

　　“Cyclosporine is very effective for relieving the signs and symptoms of dry eye, but stiging upon instillation that occurs particularly when initiating its use may lead to noncompliance,” Dr. Schechter said. “Consequently, patients may become discouraged early on because it may take several weeks before symptomatic improvement. In addition, patients with dry eye are frequently uncomfortable due to their ocular surface changes. With its analgesic activity, ketorolac can help mitigate patient symptoms and stinging with cyclosporine administration and thereby enhance therapeutic compliance, which is critical for achieving efficacy.”

　　“环孢霉素A在缓解干眼症的体征和症状方面非常有效，但是点药时的刺痛感，刚开始应用时尤为明显，可能会导致依从性下降，”Dr. Schechter说：“症状改善通常需要数周时间，结果就是，患者在一开始就可能不愿继续用药。此外，干眼症眼表的改变也常常让患者感到不适。酮咯酸的止痛效应可以缓解疾病症状，和点滴环孢霉素A时的刺痛感，从而提高治疗的依从性。疗效实现的关键正是依从性。”

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