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表1Decorin对TGFβ1和αSMA水平的影响（略）
aP<0.05 vs 0.1mg/L；bP<0.01 vs 对照组
在免疫、创伤和手术等因素导致房水屏障的破坏，激活，释放出成熟的TGFβ1等生长因子，出现细胞的异常迁移，增殖及分化及细胞外基质蛋白的形成和聚集，促使了PCO的发生和发展。而decorin通过抑制TGFβ1的分泌和拮抗TGFβ1的活性，从而可以减少PCO的发生和发展。目前decorin主要用于抗纤维化瘢痕和肿瘤的研究，尚没有用于后发性白内障的研究，所以有待进一步深入地应用于防治后发性白内障的研究。由于decorin特异性强、没有免疫原性、组织相容性好，将有望成为最具潜力的防治PCO的药物之一。
图1对照组与decorin各浓度组的免疫细胞化学染色结果（略）
A：αSMA表达的细胞胞体肥大梭形，胞质呈棕黄色;B:10mg/L；C:1.0mg/L;D: 0.1mg/L; E:培养6d
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