¡¡¡¡Our study revealed that the significant association between RNFL thickness and MD, and verified the relationship between the defects of RNFL and the losses of the visual field.The mean sensitivities at four sectors in the POAG with highly myopia group were significant relevant to the RNFL thicknesses at the according sites. What¬ðs more the losses of visual field in the POAG with highly myopia group were more serious than other groups verifying that the retinal functions were damaged by both POAG and highly myopia. The defects of RNFL in the POAG with nonª²highly myopia group were more serious when compared with that in the highly myopia without POAG group, the same as the losses of visual field in those groups. Compared with the normal control group the RNFL thickness in the highly myopia without POAG group decreased ,which revealed damage to a certain extent. But when it compared with the POAG groups both the defect of RNFL and losses of visual field were less serious.

¡¡¡¡In some cases though the nerve fiber defected in same parts, the mean sensitivity in the according sectors remained unchangeable while for some other cases the RNFL thickness remained unchangeable even if there was significant losses of visual field. The possible mechanisms[10] are as follows: in the early stage of glaucoma, RNFL defects may not affect the retinal function. On the other hand generally at the fovea every cone cell is connected by three ganglion cells, even if several cells were damaged, the others made the compensation. It¬ðs reported that there may be small changes in the central of the visual field, even if more than 20%ª²40% ganglion cells were dead. Besides the variation in RNFL, the refraction and scattering of the retinal endothecium make the differences even significant.

¡¡¡¡With the result of the Humphrey Field Analyzer, we found that in the total deviation probability plots, the regional defects were difficult to be found for nearly 77%patients turning up with general sensitivity decreasing in the POAG with highly myopia group, however the pattern deviation probability plots which get rid of the opacity of refracting media were sensitive to the early defects. The degeneration changes in highly myopia result in losing of general sensitivity in the visual field, which might be confused with the early changes of glaucoma. So the pattern deviation probability plots were more useful for our diagnoses. The results of MD in the POAG with nonª²highly myopia group were higher than those in highly myopia without POAG group, but lower than those in the POAG with highly myopia group, which suggested that the visual field changes are more specific for the glaucoma patients at the progressive stage, and when those patients are combining with highly myopia the losing of visual field might be even worse.

¡¾²Î¿¼ÎÄÏס¿
  ¡¡¡¡1 Chihara E, Liu X, Dong J, Takashima Y, Akimoto M, Hangai M, Kuriyama S, Tanihara S, Hosoda M, Tsukahara S. Severe myopia as a risk factor for progressive visual field loss in primary openª²angle glaucoma. Ophthalmologica 1997;211(9):66ª²71

¡¡¡¡2 Yuan YS, Chen XM. Contemporary clinical field of vision detect. Beijing, People health publishing 1999;51(6):186ª²198

¡¡¡¡3 Zheng YZ, Wang SH. Bathomorphic epidemiology. Ophthalmology 2001;10(5):301ª²303

¡¡¡¡4 Xu L, Chen JH, Li JJ, Luo L, Yang H, Zhang RX, Sun XY, Zheng YY, Song WX, Shi YY, Zhang SY, Zhao JJ, Ma BR . Prevalence survey and screening method of primary open angle with high myopia in coutryside and city definite crowd in Beijing. China Ophthalmology 2004;40(6):726ª²732

¡¡¡¡5 Li JJ, Xu L, Zhang R, Yang H, Sun XY, Zou Y, Ma YN, Chen YJ. Relation of primary open angle glaucoma and myopia. Ophthalmology 2004;13(3):168ª²171

¡¡¡¡6 Greve EL, Furuno F. Myopia and glaucoma. Albrecht Von Graefes Arch Klin Exp Ophthalmol 1980;213(11):33ª²41

¡¡¡¡7 Liu X, Ling YL, Luo RJ, Ge J, Zhou WB, Zheng XP. Measure normal retinal nerve fibre layer using optics cohering tomography. China Ophthalmology 2000;36(9):362ª²365

¡¡¡¡8 Jonas JB,Hayreh SS.Localized retinal nerve fiber layer defects in chronic experimental high pressure glaucoma in rhesus money. Br J Ophthalmol 1999;83(3):1291ª²1295

¡¡¡¡9 Liu H, Bian CJ, Yuan JR. Electroretinogram and visual evoked potential of the rabbit with acute intraocular hypertension. Nanjing Medical College Journal 2000;20(4):266ª²268

¡¡¡¡10 Kanamori A, Nakamura M, Escano MF, Seya R, Maeda H, Negi A. Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography. Am J Ophthalmol 2003;135(7):513ª²520

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