Meta-analysis of randomized controlled trials comparing travoprost with latanoprost in the treatment of patients with open angle glaucoma or ocular hypertension

　　程金伟 魏锐利

　　第二军医大学附属长征医院眼科 200003

　　Purpose:This meta-analysis was to evaluate the efficacy and tolerability of travoprost compared with latanoprost in patients with open angle glaucoma or ocular hypertension.

　　Method:Randomized controlled trials comparing travoprost with latanoprost in patients with open angle glaucoma or ocular hypertension were selected.The main efficacy measures were the weighted mean difference(WMD)in the IOP reduction(IOPR).

　　Results:eventeen studies enrolling a total of 1491 patients were included in the meta-analysis.The WMDs in the diurnal mean IOPR comparing travoprost with latanoprost were 1.47 mm Hg at 2 weeks，0.81 at 1 month，0.71 at 2 months，0.01 at 3 months，and 0.27 at 6 months.The WMDs in the 17∶00 IOPR were 0.87 mm Hg at 2 weeks，0.60 at 1 month，0.65 at 2 months，0.04 at 3 months，and 0.30 at 12 months.

　　Conclusions:Travoprost and latanoprost was comparable in their ability to reduce IOP.