【摘要】　目的　评价角膜缘组织移植治疗眼表疾病的临床效果。方法　对50例（51只眼）眼表疾病患者分别采用自体角膜缘、结膜移植术，新鲜异体板层角膜联合自体角膜缘移植术，新鲜异体板层角膜联合异体角膜缘移植术治疗，并随访观察术后疗效。结果　18例自体角膜缘、结膜移植患者术后均治愈。新鲜异体板层角膜联合自体角膜缘移植术20例中，19例眼表结构恢复正常，10例视力提高2行或以上。新鲜异体板层角膜联合异体角膜缘移植术12例（13只眼）中，4例发生植片溃疡，4例发生免疫排斥反应，预后较差。结论　对于单眼患者，行自体角膜缘组织移植术疗效理想。对于双眼患者，联合角膜缘组织移植术尚待进一步完善，以解决术后免疫排斥反应等问题。

　　A preliminary report of ocular surface disease treated by limbal transplantation

　　XIE Lixin, DONG Xiaoguang, SHI Weiyun, et al.

　　(Shandong Institute of Ophthalmology, Qingdao 266071, China)

　　【Abstract】　Objective　To evaluate the effect of ocular surface disease treated by limbal transplantation. Methods　In a prospective study, 5l eyes of 50 patients were treated with three kinds of surgical techniques: first, conjunctival limbal autograft (CLAU) transplantation; second, corneal lamellar allograft combined with limbal autograft transplantation and third, corneal lamellar allograft combined with limbal allograft transplantation. Their effects were evaluated. Results　All of the 18 patients of CLAU group were cured. The second surgical technique resulted in restoration of a stable ocular surface in 19 of 20 cases. 10 patients' visual acuities were improved two or more than two lines. 13 eyes of 12 patients were treated with the third surgical technique, resulting in graft ulceration in 4 patients and graft rejection in 4 patients with bad prognosis. Conclusions　The effect of unilateral ocular surface disease treated with limbal autograft transplantation is satisfactory. For bilateral ocular surface disease, the method of limbal allograft transplantation should be improved to resolve some problems such as graft rejection.

　　【Key words】　Limbus, corneal；　Transplantation, homologous

　　眼表疾病（ocular surface disease, OSD）是当今眼科界面临的棘手疾病之一。眼表疾病主要因角膜缘干细胞的破坏所致，角膜缘干细胞缺损常导致角膜新生血管化、持续上皮缺损、瘢痕、溃疡，甚至穿孔。传统的治疗方法包括单纯浅表角膜部分切除、穿透或板层角膜移植，但常因重新结膜化而失败。随着角膜缘干细胞理论的

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