精彩推荐:青光眼 白内障 近视 远视 散光 斜视弱视 角膜溃疡 角膜炎 沙眼 眼外伤 更多疾病
大众频道
专业频道
时尚频道
互动频道
疾 病 | 保 健 | 爱眼动态 | 名医名院
知 识 | 美 食 | 自检自测 | 爱眼纪事
资 讯 | 临 床 | 学 术 | 文 献
图 谱 | 医 患 | 继 教 | 家 园
五官之美 | 整 形 | 美 容
眼镜一族 | 妆 容 | 图 库
眼科在线 | 预留位置
眼科知道 | 在线咨询
  当前位置:当前位置: 中华眼科在线 → 医学频道 → 临床医学 → 论文汇集 → 正文 切换到繁體中文 用户登录 新用户注册
丝裂霉素联合地塞米松对LASEK术后haze形成的抑制作用的研究

http://www.cnophol.com 2009-4-23 15:30:15 中华眼科在线


  综上所述,LASEK联合低浓度的MMC(0.02%MMC)及地塞米松是一种安全、有效、预测性好的屈光手术。术中0.02% MMC的应用及术后短期高浓度强效糖皮质激素的冲击加后期低浓度糖皮质激素的维持使用,既在早期有效地抑制了haze形成又避免了长期应用带来的副作用,使术后haze的程度及发生率进一步降低,从而使LASEK术得到了更好的开展。


  Mitomycin-C combined dexamethasone for the treatment ofhaze 8fter LASEK. WANG Min, Ⅳ Zhen—guo,XU Zhao—hui,et a1.Lanzhou University,Lanzhou,Gansu 730000,China

  Abstract:Objective To investigate the inhibitory effect ofusing 0.02% mitomycin—C(MMC)during LASEK operation com—


  bined with dexamethasone(DM)in the postoperative short period(1 week)on the formation of haze.Methods According to differentmedication,208 patient performed LASEK were divided intoMMC group(101 patients,199 eyes)and MMC+DM group(107patient% ,200 eyes).Incidence rates of haze in the two groupswere statisticaly analyzed.Results The grade II haze was foundin 10 eyes(5.03%)and higher than grade I1 haze was not found in MMC group.Nether grade lI nor higher than grade II haze was found in MMC +DM group.The difference of incidence rates ofhaze in the same sex was statistically significant(P <0.05 ).Conclusion Th e form ation of eolTleal haze was effectively inhibi—ted by using 0.02% MMC during LASEK combined with DM intheshortpostoperative period(1 week).


  Key words:mitomycin—C;dexamethasone;laser subepitheli—al keratomileusis;haze


  参考文献:


  [1] 孙兆青,张玉红,曾芳.LASEK治疗高度近视不同性别Haze反应的I临床观察[J].潍坊医学院学报2007,29(3)277.


  [2] Wilson SE,Kim WJ.Keratoeyte apoptosis:implications on cornealwound healing,tissue organization,and disease[J].Invest Ophthat—mol Vis Sci,1998;39(2):220-226.


  [3] Wilson SE,Mohan RR,Hang Jw.T}le wound healing response pho—torefraetive keratecto my and photore fractive keratectomy:elusive con—trol of biological variability an d efect on custom laser vision correction
[J].Arch Ophthalmol,2001;119(6):889-896.


  [4] Kim TI,Lee SY,Pak JH,et a1.Mitomyein C,eeramide,and 5-fluorouracil inhibit corneal haze and apoptosis after PRK[J].Cornea,2006;25(1):55-60.


  [5] Bedei A,Marabotti A,Giannecehini I,et a1.PRK in high myopicdefects with or without intraoperative mitomycin C:1一year results[J].
Eur J Ophthalmol,2006;16(2):229-234.


  [6] Mirza MA,Qaz MA,Pepose JS.Treatment of dense subepithetial cornealhaze after laser—assisted subepithelial keratectomy『J].J Cataract  Refract Surg 2004;30(5):709-714.


  [7] Majmudar PA,Fomtot SL,Dennis RF.Topical mitomycin—C for sub—epithelial fibrosis after refractive corueal surgery[J].Ophthalmology20oO;107(6):892-894.


  [8] Tani E,Katakami C,Nesl A.Efects of various eye drops on corneal wound healing after superficial keratectomy in rabbits[J J.Jpn J Oph—thalmol,2002;46(5):488-495.


  [9] Vetrugno M,Maino A,Quo ta GM.The efect ofearly steroid treatment after PRK on clinical and refractive outcomes『J].Acta Ophthal—mol Scand,2001;79(1):23-27.


  [1O]Weber BA,Gan L,Fagerholm PP.Short—term impact of cortieoste—roids on hyaluronan and epitheiial hyperplasia in the rabbit cornea afterphotorefraetive keratectomyf J].Cornea,200l;20:321-324.

 

上一页  [1] [2] [3] [4] [5] 

(来源:中华眼科在线)(责编:zhanghui)

发表评论】【加入收藏】【告诉好友】【打印此文】【关闭窗口
  • 下一条信息:
  • 更多关于(中华眼科在线,角膜磨镶术,丝裂霉素C,地塞米松,准分子激光上皮下角膜磨镶术,角膜上皮下雾状浑浊)的信息
      热门图文

    决定女人健康的14个部

    祛除鱼尾纹so easy

    增加眼睛明亮度的八个

    张梓琳全新清新性感熟
      健康新看点
      健康多视点
      图话健康

    Copyright © 2007 中华眼科在线 网站备案序列号: 京ICP备08009675号
    本网站由五景药业主办 北京金鼎盛世医学传媒机构负责运营 国家医学教育发展中心提供学术支持
    服务电话:010-63330565 服务邮箱: [email protected]