综上所述,LASEK联合低浓度的MMC(0.02%MMC)及地塞米松是一种安全、有效、预测性好的屈光手术。术中0.02% MMC的应用及术后短期高浓度强效糖皮质激素的冲击加后期低浓度糖皮质激素的维持使用,既在早期有效地抑制了haze形成又避免了长期应用带来的副作用,使术后haze的程度及发生率进一步降低,从而使LASEK术得到了更好的开展。
Mitomycin-C combined dexamethasone for the treatment ofhaze 8fter LASEK. WANG Min, Ⅳ Zhen—guo,XU Zhao—hui,et a1.Lanzhou University,Lanzhou,Gansu 730000,China
Abstract:Objective To investigate the inhibitory effect ofusing 0.02% mitomycin—C(MMC)during LASEK operation com—
bined with dexamethasone(DM)in the postoperative short period(1 week)on the formation of haze.Methods According to differentmedication,208 patient performed LASEK were divided intoMMC group(101 patients,199 eyes)and MMC+DM group(107patient% ,200 eyes).Incidence rates of haze in the two groupswere statisticaly analyzed.Results The grade II haze was foundin 10 eyes(5.03%)and higher than grade I1 haze was not found in MMC group.Nether grade lI nor higher than grade II haze was found in MMC +DM group.The difference of incidence rates ofhaze in the same sex was statistically significant(P <0.05 ).Conclusion Th e form ation of eolTleal haze was effectively inhibi—ted by using 0.02% MMC during LASEK combined with DM intheshortpostoperative period(1 week).
Key words:mitomycin—C;dexamethasone;laser subepitheli—al keratomileusis;haze
参考文献:
[1] 孙兆青,张玉红,曾芳.LASEK治疗高度近视不同性别Haze反应的I临床观察[J].潍坊医学院学报2007,29(3)277.
[2] Wilson SE,Kim WJ.Keratoeyte apoptosis:implications on cornealwound healing,tissue organization,and disease[J].Invest Ophthat—mol Vis Sci,1998;39(2):220-226.
[3] Wilson SE,Mohan RR,Hang Jw.T}le wound healing response pho—torefraetive keratecto my and photore fractive keratectomy:elusive con—trol of biological variability an d efect on custom laser vision correction [J].Arch Ophthalmol,2001;119(6):889-896.
[4] Kim TI,Lee SY,Pak JH,et a1.Mitomyein C,eeramide,and 5-fluorouracil inhibit corneal haze and apoptosis after PRK[J].Cornea,2006;25(1):55-60.
[5] Bedei A,Marabotti A,Giannecehini I,et a1.PRK in high myopicdefects with or without intraoperative mitomycin C:1一year results[J]. Eur J Ophthalmol,2006;16(2):229-234.
[6] Mirza MA,Qaz MA,Pepose JS.Treatment of dense subepithetial cornealhaze after laser—assisted subepithelial keratectomy『J].J Cataract Refract Surg 2004;30(5):709-714.
[7] Majmudar PA,Fomtot SL,Dennis RF.Topical mitomycin—C for sub—epithelial fibrosis after refractive corueal surgery[J].Ophthalmology20oO;107(6):892-894.
[8] Tani E,Katakami C,Nesl A.Efects of various eye drops on corneal wound healing after superficial keratectomy in rabbits[J J.Jpn J Oph—thalmol,2002;46(5):488-495.
[9] Vetrugno M,Maino A,Quo ta GM.The efect ofearly steroid treatment after PRK on clinical and refractive outcomes『J].Acta Ophthal—mol Scand,2001;79(1):23-27.
[1O]Weber BA,Gan L,Fagerholm PP.Short—term impact of cortieoste—roids on hyaluronan and epitheiial hyperplasia in the rabbit cornea afterphotorefraetive keratectomyf J].Cornea,200l;20:321-324.
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