GUO Shuo  WEI Shi-hui

Department of Ophthalmology， the First Hospital of Qhuangdao City ，Hebei， China Department of Ophthalmology； Chinese General Hospital of PLA； Beijing  China100853

Objective：To investigate the relativity between optic neuritis and multiple sclerosis(MS)， to estimate the importance of methylprednisolone for multiple sclerosis.Methods： Collection of 85 MS in- patient cases which were admitted from year 2001 to year 2005 ， Those systemic and ocular symptoms， correlated examinations and therapy were analyzed by SPSS12.0.Results ： 40%(34/85) of the MS patients broke out as 0ptic Neuritis and 23.53%(20/85) of them initially broke out as optic neuritis. After statistical analysis of correlated examinations ，the rate of head MRI-positive result in optic neuritis patients was higher than that in patients without eye symptom.P<0.05，χ2=6.28. The rate of neck MRI-positive result in optic neuritis patients was higher than that in patients without eye symptom. P<0.05，χ2=4.87.After large dose methylprednisolone and gammaglobulin for MS， 69.4%(59/85) of the MS patients recovered and 21.2%(18/85)of them relieved. visual acuity 0f 31 cases improved. Conclusions：When optic neuritis patients visit in department of ophthalmology，they should have a MRI to exclude MS. Large dose methylprednisolone and gammaglobulin for MS is the first way.

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