【摘要】 目的 了解泪液缺乏型干眼患者的角膜内皮细胞密度和形态的改变。方法 应用ＳＰ２０００Ｐ型角膜内皮计对２００５年８月至２００６年２月于我院门诊就诊的２０例（３２眼）典型泪液缺乏型干眼患者进行角膜内皮细胞照相，并以２３例（３６眼）正常人作为对照，对两组角膜内皮细胞密度及形态进行分析和比较。 结果 泪液缺乏型干眼组的角膜内皮细胞密度为（２６０５.４±３１６.９）个／ｍｍ２，内皮细胞平均面积为（３８９.３±４７.１）?滋ｍ２；正常对照组角膜的内皮细胞密度为（２６０７.９±３１３.３）个／ｍｍ２，内皮细胞平均面积为（３８８.７±４５.３）?滋ｍ２，两组比较差异无显著性。泪液缺乏型干眼组内皮细胞平均面积变异系数为（３７.３±１０.１）％，角膜内皮六边形细胞比例为（５２.３±８.９）％；正常对照组内皮细胞平均面积变异系数为（３５.３±４.７）％，角膜内皮六边形细胞比例为（４７.５±１０.９）％，两组比较差异无显著性。 结论 泪液缺乏型干眼患者与正常人相比，角膜内皮细胞密度和形态无明显改变。
【关键词】 干眼；泪液缺乏；角膜内皮；细胞密度；细胞形态
Ｃｏｒｎｅａｌ ｅｎｄｏｔｈｅｌｉａｌ ｃｅｌｌ ｄｅｎｓｉｔｙ ａｎｄ ｍｏｒｐｈｏｌｏｇｙ ｉｎ ａｑｕｅｏｕｓ ｔｅａｒ ｄｅｆｉｃｉｅｎｃｙ ｅｙｅｓ
ＺＯＵ Ｗｅｎｊｉｎ，ＬＩＵ Ｚｕｇｕｏ，ＬＩＡＮＧ Ｌｉｎｇｙｉ，ｅｔ ａｌ.
Ｚｈｏｎｇｓｈａｎ Ｏｐｈｔｈａｌｍｉｃ Ｃｅｎｔｅｒ，Sｔａｔｅ Ｋｅｙ Lａｂｏｒａｔｏｒｙ ｏｆ Ｏｐｈｔｈａｌｍｏｌｏｇｙ，ＳＵＮ Ｙａｔ－ｓｅｎ Ｕｎｉｖｅｒｓｉｔｙ， Ｇｕａｎｇｚｈｏｕ Ｃｈｉｎａ，５１００６０
［Ａｂｓｔｒａｃｔ］ Ｏｂｊｅｃｔｉｖｅ To investigate corneal endothelial cell density and morphology of aqueous tear deficiency (ATD) in dry eye patients. Methods A specular microscope was used to examine 20 typical dry eye patients with aqueous tear deficiency and 23 age- and gender-matched normal people who were used as controls. Mean cell density (MCD), mean cell area (MCA), coefficient of variation (CV) in cell size (polymegathism), and hexagonality were recorded and analyzed. Results MCD was （2605.4±316.9） cells/mm2 and MCA was （389.3±47.1）?滋m2 in aqueous tear deficiency eyes and there was no significant difference when compared to normal controls, in which MCD was （2607.9±313.3） cells/mm2 and MCA was （388.7±45.3）?滋m2. CV in cell size was （37.3±10.1）％ and hexagonality was （52.3±8.9）％ in aqueous tear deficiency eyes and these values did not differ significantly from normal controls either. Conclusion There were no statistically significant differences in MCD, MCA, and CV in cell size or hexagonality when dry eye patients with aqueous tear deficiency and normal controls were compared.
［ｋｅｙ ｗｏｒｄｓ］ ｄｒｙ ｅｙｅ; ａｑｕｅｏｕｓ ｔｅａｒ ｄｅｆｉｃｉｅｎｃｙ; ｃｏｒｎｅａｌ ｅｎｄｏｔｈｅｌｉｕｍ; ｃｅｌｌ ｄｅｎｓｉｔｙ; ｃｅｌｌ ｍｏｒｐｈｏｌｏｇｙ
干眼是最常见的眼表疾病，泪液缺乏型干眼是其中的一大类，包括Ｓｊ?觟ｇｒｅｎ 综合征、非Ｓｊ?觟ｇｒｅｎ 综合征的泪液缺乏型干眼以及其他的一些疾病。泪液缺乏型干眼的特点是泪液分泌量减少，并导致典型的干眼症状及眼表损害。长期干眼将会因炎症而产生眼表的一些病理改变，如角膜厚度变薄［１］，角膜基质中神经纤维扭曲、分叉、数目增多［２］。我们推测长期炎症亦可能对角膜内皮细胞造成影响，为此，我们对２０例泪液缺乏型干眼患者及２３例正常人进行角膜内皮细胞计数及内皮细胞形态分析，并进行比较。现将结果报告如下。
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