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糖尿病视网膜病变发病机制研究进展

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9 Li J,Hu YH.Susceptibility genes for diabetic retinopathy. Int J Ophthalmol (Guoji Yanke Zazhi) 2008;8(2):234239

10 Cheung AK, Fung MK, Lo AC, et al. Aldose reductase deficiency prevents diabetesinduced bloodretinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice. Diabetes 2005;54(11):31193125

11 Sun W, Oates PJ, Coutcher JB, et al. A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy. Diabetes 2006;55(10):2757 2762

12 Wautier JL, Guillausseau PJ. Advanced glycation end products, their receptors and diabetic angiopathy. Diabete Metab 2001;27(5):535542

13 Stitt AW, Li YM, Gardiner TA, et al. Advanced glycation end products (AGEs) colocalize with AGE receptors in the retinal vasculature of diabetic and of AGEinfused rats. Am J Pathol 1997;150(2):523531

14 LecleireCollet A, Tessier LH, Massin P, et al. Advanced glycation end products can induce glial reaction and neuronal degeneration in retinal explants. Br J Ophthalmol 2005;89(12):16311633

15 Moore TC, Moore JE, Kaji Y, et al. The role of advanced glycation end products in retinal microvascular leukostasis. Invest Ophthalmol Vis Sci 2003;44(10):4457 4464

16 Li WL, Jiang DY, Guo LH, et al. Pueravin inhibits the prociferation of human retinal pigment epithelial cells and the expression of hypoxiainducible factor1α in human PRE cells induced by advanced glycation end products. Int J Ophthalmol(Guoji Yanke Zazhi) 2006;6(3):580583

17 Treins C, GiorgettiPeraldi S, Murdaca J, et al. Regulation of vascular endothelial growth factor expression by advanced glycation end products. J Biol Chem 2001;276(47):43836 43841

18 Antonetti DA, Barber AJ, Hollinger LA, et al. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem 1999;274(33):2346323467

19 Agardh E, Hultberg B, Agardh C. Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats. Curr Eye Res 2000;21(1):543549

20 Kern TS, Engerman RL. Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin. Diabetes 2001;50(7):16361642

21 Kern TS, Tang J, Mizutani M, et al. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: comparison of diabetes and galactosemia. Invest Ophthalmol Vis Sci 2000;41(12):39723978

22 Lu TT, Yan LG, Madri JA. Integrin engagement mediates tyrosine dephosphorylation on plateletendothelial cell adhesion molecule 1. Proc Natl Acad Sci USA 1996;93(21):1180811813

23 Bursell SE, Clermont AC, Kinsley BT, et al. Retinal blood flow changes in patients with insulindependent diabetes mellitus and no diabetic retinopathy. Invest Ophthalmol Vis Sci 1996;37(5):886 897

24 Miyamoto K, Ogura Y, Nishiwaki H, et al. Evaluation of retinal microcirculatory alterations in the GotoKakizaki rat. A spontaneous model of noninsulindependent diabetes. Invest Ophthalmol Vis Sci 1996;37(5):898905

25 Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994;331(22):14801487

26 MacGregor LC, Matschinsky FM. Altered retinal metabolism in diabetes. II. Measurement of sodium potasium ATPase and total sodium and potassium in individual retinal layers. J Biol Chem 1986;261(9):4052 4058

27 Du Y, Miller CM, Kern TS. Hyperglycemia increases mitochondrial superoxide in retina and retinal cells. Free Radic Biol Med 2003;35(11):14911499

28 Cui Y, Xu X, Bi H, et al. Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: the role of reactive oxygen species in diabetic retinopathy. Exp Eye Res 2006;83(4):807 816

29 Cutler RG. Oxidative stress profiling:part I. Its potential importance in the optimization of human health. Ann N Y Acad Sci 2005;1055:93135

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