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人类角膜内皮细胞免疫学特征的初步发现

http://www.cnophol.com 2009-12-28 14:31:31 中华眼科在线

  作者:王帆,宋柏林,郭红阳    作者单位:(作者单位:1德国法兰克福歌德大学医院眼科;2130021 中国吉林省长春市,长春中医药大学附属医院眼科)

  【摘要】  目的:评价人类角膜内皮细胞作为免疫细胞的功能。方法:免疫组织化学染色方法测定人类角膜内皮细胞,分别在有无γ干扰素诱导条件下的HLAII类抗原﹑CD40抗原的表达。体外共同培养人类角膜内皮细胞和外周血单个核细胞,FACS测定共同培养体系中活化的T淋巴细胞中CD69的表达。结果:γ干扰素能够诱导HLAII类抗原和共同刺激通路中CD40的表达,T淋巴细胞在人类角膜内皮细胞和外周血单个核细胞共同培养系统中被激活结论:人类角膜内皮细胞作为潜在的抗原递呈细胞参与角膜移植排斥反应。

  【关键词】  抗原递呈细胞;人类角膜内皮细胞;外周血单个核细胞;共同刺激通路;荧光辅助细胞筛选分析

  The Organizing Committee of the Asia Pacific Academy of Ophthalmology (APAO) Congress is proud to announce that the prestigious APAO Congress will be held in Sydney, Australia from 2124 March 2011. The APAO Sydney2011 Congress is being hosted by the Royal Australian and Zealand College of Ophthalmologists (RANZCO). As the professional association for Ophthalmologists throughout Australia and New Zealand, RANZCO is delighted to host the Congress. With a very successful World Congress having been held in Sydney in 2002, the Organising Committee is dedicated to ensuring that the high standard and continued success of previous congresses is maintained.

  We look forward to and welcome your participation in Sydney in 2011.

  (quote from www.apaosydney2011.com)·Original article·

  Surgical treatment for traumatic cataract

  Zhe Xu1, HongBo Yin2, Yi Liu2

  1Chengdu Aier Eye Hospital,Chengdu 610041,Sichuan Province,China

  2Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041,Sichuan Province,China

  Abstract

  AIM: To study the therapeutic effect of surgical treatment for traumatic cataract.

  METHODS: Seventythree cases(73 eyes) traumatic cataract were performed multioperation combined cataract extraction, including insertion of a capsular tension ring(CTR), vitreoretinal surgery, ocular foreign body extraction and intraocular lens(IOL) implantation.

  RESULTS: Of 73 patients, twentyseven cases were blunt trauma, while 46 cases were penetrating injuries. Three months after surgery, the final best spectaclecorrected visual acuity(BSCVA) in 5 patients (7%) were 0.05 or less, seventeen(23%) 0.05 to 0.3, while 49(67%) 0.3 or more. There were 93% cases relieved from blindness. Atrophy of eyeball occurred in two cases(3%). Mean followup time was 7.8(range 315) months.

  CONCLUSION: Useful vision can be restored in a proportion of traumatic cataracts after prompt and rational surgical intervention as well as appropriate treatment of sightthreaten complications.

  KEYWORDS: ocular trauma; cataract; combined surgery

  INTRODUCTION

  Traumatic cataract is the main cause of unilateral blindness following accidental injuries to the eye. Children and young adults are the most likely victims. Traumatic cataract is often associated with corneal or corneoscleral lacerations, iridodialysis, lens dislocation, vitreous hemorrhage, retinal detachment and ocular foreign body requiring combined surgical treatment. We evaluate our experience of traumatic cataracts surgery in order to achieve better visual acuity.

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(来源:互联网)(责编:xhhdm)

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